Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27kip1, p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma

Pier Paolo Claudio, Alessandra Zamparelli, Fernando U. Garcia, Luigi Claudio, Giuseppe Ammirati, Antonio Farina, Alessandro Bovicelli, Giuseppe Russo, Giovan Giacomo Giordano, David E. McGinnis, Antonio Giordano, Gaetano Cardi

Research output: Contribution to journalArticle

Abstract

Purpose: The quest for prognostic molecular markers in prostatic carcinoma is still in progress. Many proteins have already been screened by immunohistochemistry with the aim to find the most reliable indicator of progressive disease. In this study, we evaluated the expression of pRb2/ p130, p107, p27kip1, p53, mdm-2, and Ki-67 (MIB-1) by immunohistochemistry in 24 prostate carcinomas compared with the paired expression of normal prostates. Experimental Design: Expression of the different proteins in normal and pathological specimens was evaluated by the Wilcoxon test. A matrix of correlation (Spearman coefficient) was used to evaluate the possible association in expression among the different proteins. Logistic regression analysis was used to test the multivariable prognostic value of the levels of protein expression for the probability of disease development. Results: p53 and Ki-67 (MIB-1) showed a higher expression in cancer than in normal tissue (P = 0.006 and kip1 showed an overall lower expression in cancer, but the difference between cytoplasmic and nuclear expression was always higher for cancer (Ps, from

Original languageEnglish
Pages (from-to)1808-1815
Number of pages8
JournalClinical Cancer Research
Volume8
Issue number6
Publication statusPublished - 2002

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Cell Cycle Proteins
Adenocarcinoma
Prostate
Proteins
Immunohistochemistry
Carcinoma
Neoplasms
Research Design
Logistic Models
Regression Analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Claudio, P. P., Zamparelli, A., Garcia, F. U., Claudio, L., Ammirati, G., Farina, A., ... Cardi, G. (2002). Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27kip1, p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma. Clinical Cancer Research, 8(6), 1808-1815.

Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27kip1, p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma. / Claudio, Pier Paolo; Zamparelli, Alessandra; Garcia, Fernando U.; Claudio, Luigi; Ammirati, Giuseppe; Farina, Antonio; Bovicelli, Alessandro; Russo, Giuseppe; Giordano, Giovan Giacomo; McGinnis, David E.; Giordano, Antonio; Cardi, Gaetano.

In: Clinical Cancer Research, Vol. 8, No. 6, 2002, p. 1808-1815.

Research output: Contribution to journalArticle

Claudio, PP, Zamparelli, A, Garcia, FU, Claudio, L, Ammirati, G, Farina, A, Bovicelli, A, Russo, G, Giordano, GG, McGinnis, DE, Giordano, A & Cardi, G 2002, 'Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27kip1, p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma', Clinical Cancer Research, vol. 8, no. 6, pp. 1808-1815.
Claudio, Pier Paolo ; Zamparelli, Alessandra ; Garcia, Fernando U. ; Claudio, Luigi ; Ammirati, Giuseppe ; Farina, Antonio ; Bovicelli, Alessandro ; Russo, Giuseppe ; Giordano, Giovan Giacomo ; McGinnis, David E. ; Giordano, Antonio ; Cardi, Gaetano. / Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27kip1, p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma. In: Clinical Cancer Research. 2002 ; Vol. 8, No. 6. pp. 1808-1815.
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AU - Garcia, Fernando U.

AU - Claudio, Luigi

AU - Ammirati, Giuseppe

AU - Farina, Antonio

AU - Bovicelli, Alessandro

AU - Russo, Giuseppe

AU - Giordano, Giovan Giacomo

AU - McGinnis, David E.

AU - Giordano, Antonio

AU - Cardi, Gaetano

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