Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27kip1, p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma

Pier Paolo Claudio, Alessandra Zamparelli, Fernando U. Garcia, Luigi Claudio, Giuseppe Ammirati, Antonio Farina, Alessandro Bovicelli, Giuseppe Russo, Giovan Giacomo Giordano, David E. McGinnis, Antonio Giordano, Gaetano Cardi

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The quest for prognostic molecular markers in prostatic carcinoma is still in progress. Many proteins have already been screened by immunohistochemistry with the aim to find the most reliable indicator of progressive disease. In this study, we evaluated the expression of pRb2/ p130, p107, p27kip1, p53, mdm-2, and Ki-67 (MIB-1) by immunohistochemistry in 24 prostate carcinomas compared with the paired expression of normal prostates. Experimental Design: Expression of the different proteins in normal and pathological specimens was evaluated by the Wilcoxon test. A matrix of correlation (Spearman coefficient) was used to evaluate the possible association in expression among the different proteins. Logistic regression analysis was used to test the multivariable prognostic value of the levels of protein expression for the probability of disease development. Results: p53 and Ki-67 (MIB-1) showed a higher expression in cancer than in normal tissue (P = 0.006 and kip1 showed an overall lower expression in cancer, but the difference between cytoplasmic and nuclear expression was always higher for cancer (Ps, from

Original languageEnglish
Pages (from-to)1808-1815
Number of pages8
JournalClinical Cancer Research
Volume8
Issue number6
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27kip1, p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma'. Together they form a unique fingerprint.

Cite this