Expression of cell surface P-glycoprotein by an Adriamycin-resistant murine fibrosarcoma

Raffaella Giavazzi, Norbert Kartner, Ian R. Hart

Research output: Contribution to journalArticlepeer-review


Analysis of the cell membrane of Adriamycin (doxorubicin)-resistant UV-2237 ADMR murine fibrosarcoma cells revealed a 170,000-dalton component that is not found in the drug-sensitive parent or revertant cells. Immunoblot (Western blot) analysis showed that this component is similar to the 170,000-dalton P-glycoprotein found on the surface of Chinese hamster ovary cells that exhibit multidrug resistance. Thus, multidrug resistance and P-glycoprotein expression apparently can occur in a wide variety of cells, including the metastatic murine solid tumor cell line described here.

Original languageEnglish
Pages (from-to)145-147
Number of pages3
JournalCancer Chemotherapy and Pharmacology
Issue number2
Publication statusPublished - Aug 1984

ASJC Scopus subject areas

  • Pharmacology
  • Oncology
  • Cancer Research


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