Expression of common acute lymphoblastic leukemia antigen (CD 10) by myelinated fibers of the peripheral nervous system

Angela Cadoni, Gian Luigi Mancardi, Damiano Zaccheo, Arcangelo Nocera, Sergio Barocci, Daria Bianchini, Angelo Schenone, Elisabetta Capello, Antonio Zicca

Research output: Contribution to journalArticle

Abstract

The common acute lymphoblastic leukemia antigen (CALLA), CD10, is a 100-kDa surface glycoprotein endowed with neutral endopeptidase activity, shared by a number of hemopoietic and non-hemopoietic cells. In this report, immunohistochemical and Western blot techniques, using different anti-CD10 monoclonal antibodies, were utilized to demonstrate that CD10 is also expressed by myelin sheaths of the human peripheral nervous system (PNS), but not of the central nervous system. CD10-positive immunoreactivity appeared to be localized in the outer and inner borders of myelinated fibers, in nodes of Ranvier and in the Schmidt-Lantermann clefts, thus showing a distribution pattern very similar to that of myelin-associated glycoprotein (MAG). The above findings suggest that CD10 antigen, through its enzymatic activity, may have a functional role in the assembly and maintenance of PNS myelin. In addition, it is not known whether CD10, similarly to MAG, may be a target antigen in some PNS immune-mediated disorders.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalJournal of Neuroimmunology
Volume45
Issue number1-2
DOIs
Publication statusPublished - Jan 1 1993

Fingerprint

Neprilysin
Peripheral Nervous System
Myelin-Associated Glycoprotein
Myelin Sheath
Autoimmune Diseases of the Nervous System
Ranvier's Nodes
Membrane Glycoproteins
Central Nervous System
Western Blotting
Monoclonal Antibodies
Maintenance
Antigens

Keywords

  • Autoimmune neurophathy
  • CD10
  • Common acute lymphoblastic leukemia antigen
  • Myelin
  • Myelin-associated glycoprotein
  • Peripheral neuropathies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Expression of common acute lymphoblastic leukemia antigen (CD 10) by myelinated fibers of the peripheral nervous system. / Cadoni, Angela; Mancardi, Gian Luigi; Zaccheo, Damiano; Nocera, Arcangelo; Barocci, Sergio; Bianchini, Daria; Schenone, Angelo; Capello, Elisabetta; Zicca, Antonio.

In: Journal of Neuroimmunology, Vol. 45, No. 1-2, 01.01.1993, p. 61-66.

Research output: Contribution to journalArticle

Cadoni, Angela ; Mancardi, Gian Luigi ; Zaccheo, Damiano ; Nocera, Arcangelo ; Barocci, Sergio ; Bianchini, Daria ; Schenone, Angelo ; Capello, Elisabetta ; Zicca, Antonio. / Expression of common acute lymphoblastic leukemia antigen (CD 10) by myelinated fibers of the peripheral nervous system. In: Journal of Neuroimmunology. 1993 ; Vol. 45, No. 1-2. pp. 61-66.
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