Expression of connective tissue growth factor (CTGF/CCN2) in a mouse model of rhabdomyosarcomagenesis

Stefania Croci, Lorena Landuzzi, Giordano Nicoletti, Arianna Palladini, Agnese Antognoli, Carla De Giovanni, Patrizia Nanni, Pier Luigi Lollini

Research output: Contribution to journalArticlepeer-review

Abstract

Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich matricellular protein that belongs to the CCN (CYR61, CTGF, NOV) protein family. It is highly expressed by human rhabdomyosarcoma cells and sustains their survival. In this study we investigated CCN2 expression in a mouse model of spontaneous rhabdomyosarcomagenesis that combines HER-2/neu oncogene activation and p53 oncosuppressor gene inactivation (BALB-p53neu mice). Murine rhabdomyosarcoma cells showed a 4-26 fold increase in CCN2 mRNA expression regarding to normal thigh muscle. Moreover, they expressed CCN2 protein at levels comparable to human rhabdomyosarcoma cells. Therefore BALB-p53neu mice might be useful for the evaluation of the role played by CCN2 in rhabdomyosarcoma in vivo.

Original languageEnglish
Pages (from-to)336-339
Number of pages4
JournalPathology and Oncology Research
Volume13
Issue number4
Publication statusPublished - 2007

Keywords

  • CCN proteins
  • CCN2/CTGF
  • Mouse model
  • Rhabdomyosarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

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