Expression of connective tissue growth factor is a prognostic marker for patients with intrahepatic cholangiocarcinoma

A. Gardini, B. Corti, M. Fiorentino, A. Altimari, G. Ercolani, G. L. Grazi, A. D. Pinna, W. F. Grigioni, A. D'Errico Grigioni

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background. Connective tissue growth factor is a member of the 'CCN' protein family. Consistent with its profibrotic properties, it is over-expressed in several human epithelial malignancies. Patients and methods. We have retrospectively evaluated by immunohistochemistry the presence of connective tissue growth factor in archival tissues from 55 resected intrahepatic cholangiocarcinomas and compared its expression to the main pathological parameters, disease free and overall survival. Results. Tumours were scored as high and low/absent expressers (≥50%, 0-50% cells, respectively). Thirty-three of 55 cholangiocarcinomas (60%) were high and 22 (40%) low expressers. No significant correlation was found between connective tissue growth factor and tumour grade, tumour location, vascular and perineural invasion. Eighteen of 22 (82%) low/absent expressers and 12/33 (36%) high expressers had recurrence of disease (P = 0.001). Low/absent expressers showed a poor disease free and overall survival compared with the higher expressers (P <0.001). Vascular invasion was related to tumour recurrence (P = 0.025) and to decreased disease free survival (P <0.05). During proportional hazard regression analysis, only connective tissue growth factor was found to influence disease free survival (P = 0.01). Conclusions. Expression of connective tissue growth factor is an independent prognostic indicator of both tumour recurrence and overall survival for intrahepatic cholangiocarcinoma patients regardless of tumour location, tumour grade, vascular and perineural invasion.

Original languageEnglish
Pages (from-to)269-274
Number of pages6
JournalDigestive and Liver Disease
Volume37
Issue number4
DOIs
Publication statusPublished - Apr 2005

Fingerprint

Connective Tissue Growth Factor
Cholangiocarcinoma
Disease-Free Survival
Neoplasms
Blood Vessels
Recurrence
CCN Intercellular Signaling Proteins
Immunohistochemistry
Regression Analysis
Survival

Keywords

  • Cholangiocarcinoma
  • Connective tissue growth factor

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Expression of connective tissue growth factor is a prognostic marker for patients with intrahepatic cholangiocarcinoma. / Gardini, A.; Corti, B.; Fiorentino, M.; Altimari, A.; Ercolani, G.; Grazi, G. L.; Pinna, A. D.; Grigioni, W. F.; D'Errico Grigioni, A.

In: Digestive and Liver Disease, Vol. 37, No. 4, 04.2005, p. 269-274.

Research output: Contribution to journalArticle

Gardini, A, Corti, B, Fiorentino, M, Altimari, A, Ercolani, G, Grazi, GL, Pinna, AD, Grigioni, WF & D'Errico Grigioni, A 2005, 'Expression of connective tissue growth factor is a prognostic marker for patients with intrahepatic cholangiocarcinoma', Digestive and Liver Disease, vol. 37, no. 4, pp. 269-274. https://doi.org/10.1016/j.dld.2004.11.001
Gardini, A. ; Corti, B. ; Fiorentino, M. ; Altimari, A. ; Ercolani, G. ; Grazi, G. L. ; Pinna, A. D. ; Grigioni, W. F. ; D'Errico Grigioni, A. / Expression of connective tissue growth factor is a prognostic marker for patients with intrahepatic cholangiocarcinoma. In: Digestive and Liver Disease. 2005 ; Vol. 37, No. 4. pp. 269-274.
@article{c8402db88f234c69a0398673929a1349,
title = "Expression of connective tissue growth factor is a prognostic marker for patients with intrahepatic cholangiocarcinoma",
abstract = "Background. Connective tissue growth factor is a member of the 'CCN' protein family. Consistent with its profibrotic properties, it is over-expressed in several human epithelial malignancies. Patients and methods. We have retrospectively evaluated by immunohistochemistry the presence of connective tissue growth factor in archival tissues from 55 resected intrahepatic cholangiocarcinomas and compared its expression to the main pathological parameters, disease free and overall survival. Results. Tumours were scored as high and low/absent expressers (≥50{\%}, 0-50{\%} cells, respectively). Thirty-three of 55 cholangiocarcinomas (60{\%}) were high and 22 (40{\%}) low expressers. No significant correlation was found between connective tissue growth factor and tumour grade, tumour location, vascular and perineural invasion. Eighteen of 22 (82{\%}) low/absent expressers and 12/33 (36{\%}) high expressers had recurrence of disease (P = 0.001). Low/absent expressers showed a poor disease free and overall survival compared with the higher expressers (P <0.001). Vascular invasion was related to tumour recurrence (P = 0.025) and to decreased disease free survival (P <0.05). During proportional hazard regression analysis, only connective tissue growth factor was found to influence disease free survival (P = 0.01). Conclusions. Expression of connective tissue growth factor is an independent prognostic indicator of both tumour recurrence and overall survival for intrahepatic cholangiocarcinoma patients regardless of tumour location, tumour grade, vascular and perineural invasion.",
keywords = "Cholangiocarcinoma, Connective tissue growth factor",
author = "A. Gardini and B. Corti and M. Fiorentino and A. Altimari and G. Ercolani and Grazi, {G. L.} and Pinna, {A. D.} and Grigioni, {W. F.} and {D'Errico Grigioni}, A.",
year = "2005",
month = "4",
doi = "10.1016/j.dld.2004.11.001",
language = "English",
volume = "37",
pages = "269--274",
journal = "Digestive and Liver Disease",
issn = "1590-8658",
publisher = "Elsevier B.V.",
number = "4",

}

TY - JOUR

T1 - Expression of connective tissue growth factor is a prognostic marker for patients with intrahepatic cholangiocarcinoma

AU - Gardini, A.

AU - Corti, B.

AU - Fiorentino, M.

AU - Altimari, A.

AU - Ercolani, G.

AU - Grazi, G. L.

AU - Pinna, A. D.

AU - Grigioni, W. F.

AU - D'Errico Grigioni, A.

PY - 2005/4

Y1 - 2005/4

N2 - Background. Connective tissue growth factor is a member of the 'CCN' protein family. Consistent with its profibrotic properties, it is over-expressed in several human epithelial malignancies. Patients and methods. We have retrospectively evaluated by immunohistochemistry the presence of connective tissue growth factor in archival tissues from 55 resected intrahepatic cholangiocarcinomas and compared its expression to the main pathological parameters, disease free and overall survival. Results. Tumours were scored as high and low/absent expressers (≥50%, 0-50% cells, respectively). Thirty-three of 55 cholangiocarcinomas (60%) were high and 22 (40%) low expressers. No significant correlation was found between connective tissue growth factor and tumour grade, tumour location, vascular and perineural invasion. Eighteen of 22 (82%) low/absent expressers and 12/33 (36%) high expressers had recurrence of disease (P = 0.001). Low/absent expressers showed a poor disease free and overall survival compared with the higher expressers (P <0.001). Vascular invasion was related to tumour recurrence (P = 0.025) and to decreased disease free survival (P <0.05). During proportional hazard regression analysis, only connective tissue growth factor was found to influence disease free survival (P = 0.01). Conclusions. Expression of connective tissue growth factor is an independent prognostic indicator of both tumour recurrence and overall survival for intrahepatic cholangiocarcinoma patients regardless of tumour location, tumour grade, vascular and perineural invasion.

AB - Background. Connective tissue growth factor is a member of the 'CCN' protein family. Consistent with its profibrotic properties, it is over-expressed in several human epithelial malignancies. Patients and methods. We have retrospectively evaluated by immunohistochemistry the presence of connective tissue growth factor in archival tissues from 55 resected intrahepatic cholangiocarcinomas and compared its expression to the main pathological parameters, disease free and overall survival. Results. Tumours were scored as high and low/absent expressers (≥50%, 0-50% cells, respectively). Thirty-three of 55 cholangiocarcinomas (60%) were high and 22 (40%) low expressers. No significant correlation was found between connective tissue growth factor and tumour grade, tumour location, vascular and perineural invasion. Eighteen of 22 (82%) low/absent expressers and 12/33 (36%) high expressers had recurrence of disease (P = 0.001). Low/absent expressers showed a poor disease free and overall survival compared with the higher expressers (P <0.001). Vascular invasion was related to tumour recurrence (P = 0.025) and to decreased disease free survival (P <0.05). During proportional hazard regression analysis, only connective tissue growth factor was found to influence disease free survival (P = 0.01). Conclusions. Expression of connective tissue growth factor is an independent prognostic indicator of both tumour recurrence and overall survival for intrahepatic cholangiocarcinoma patients regardless of tumour location, tumour grade, vascular and perineural invasion.

KW - Cholangiocarcinoma

KW - Connective tissue growth factor

UR - http://www.scopus.com/inward/record.url?scp=23044457422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23044457422&partnerID=8YFLogxK

U2 - 10.1016/j.dld.2004.11.001

DO - 10.1016/j.dld.2004.11.001

M3 - Article

C2 - 15788211

AN - SCOPUS:23044457422

VL - 37

SP - 269

EP - 274

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

SN - 1590-8658

IS - 4

ER -