Expression of cripto and amphiregulin in colon mucosa from high risk colon cancer families

Ernesto De Angelis, Michele Grassi, William J. Gullick, Gibbes R. Johnson, Giovanni B. Rossi, Alfonso Tempesta, Francesca De Angelis, Antonella De Luca, David S. Salomon, Nicola Normanno

Research output: Contribution to journalArticlepeer-review


We assessed the expression of the epidermal growth factor (EGF)-related peptides, cripto-I (CR-I) and amphiregulin (AR), in a small panel of human colon adenomas and carcinomas. CR-I immunoreactivity was found in 17/31 (55%) of colon adenomas, and in 33/39 (84%) colon carcinomas. AR immunostaining was observed in 16/26 adenomas (61%) and in 20/26 carcinomas (77%). CR-I and AR staining were also assessed in 29 specimens from 24 individuals that belong to families with high incidence of colorectal carcinoma, and in 5 non-high risk individuals. Expression of CR-I was detected in 18/29 (62%) of high risk colon mucosa specimens, but only in 1/5 (20%) specimens from non-high risk individuals, while AR staining was found in 20/29 (69%) and in 4/5 (80%) of colon mucosa samples from high and low risk individuals, respectively. A majority (21/29; 72%) of the specimens from the high risk individuals had a high proliferative rate, as measured by Ki-67 staining. A statistically significant correlation was found between high proliferative rate, increased expression of CR-I and reduced expression of AR in the mucosa specimens from high risk individuals, suggesting that these might represent early events in colon tumorigenesis.

Original languageEnglish
Pages (from-to)437-440
Number of pages4
JournalInternational Journal of Oncology
Issue number3
Publication statusPublished - Mar 1999


  • Amphiregulin
  • Colon carcinoma
  • Cripto

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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