Expression of E-cadherin and α-catenin in T1 N0 laryngeal cancer

Elisabetta Carico, Marco Radici, Nunzia Simona Losito, Salvatore Raffa, Luca Firrisi, Alfredo Fabiano, Marco Manola, Aldo Vecchione, Maria Rosaria Giovagnoli

Research output: Contribution to journalArticle

Abstract

Aim: To determine whether modulation of expression of cell adhesion molecules occurs in neoplastic transformation of laryngeal epithelium and to investigate their possible role in clinical outcome. Materials and Methods: Fifty-five T1 N0 laryngeal biopsies were tested by immunohistochemistry for the E-cadherin/α-catenin adhesion complex. Results: High immunohistochemical expression of E-cadherin and α-catenin was found in 18% and 53% cases, respectively. Expression of both adhesion molecules decreased according to histological grading; a significant relationship was particularly found between high E-cadherin expression and G1 cases (p=0.013). High E-cad-herin expression was statistically associated with in situ carcinoma (p=0.006). Non-statistical significance was evidenced between these adhesion molecules and tobacco use or site of occurence. Regarding clinical outcome, recurrence was associated with low expression of both adhesion molecules. Conclusion: E-cadherin and α-catenin down-regulation might be associated with neoplastic transformation in laryngeal tissues and might be regarded as a risk factor for clinical recurrence.

Original languageEnglish
Pages (from-to)5245-5249
Number of pages5
JournalAnticancer Research
Volume32
Issue number12
Publication statusPublished - Dec 2012

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Keywords

  • A-catenin
  • Adhesion molecules
  • E-cadherin
  • Immunohistochemistry
  • Laryngeal cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Carico, E., Radici, M., Losito, N. S., Raffa, S., Firrisi, L., Fabiano, A., Manola, M., Vecchione, A., & Giovagnoli, M. R. (2012). Expression of E-cadherin and α-catenin in T1 N0 laryngeal cancer. Anticancer Research, 32(12), 5245-5249.