Expression of epidermal growth factor receptor and transforming growth factor α in human larynx carcinoma

Eddi Di Marco, Enrico Albanese, Stefano Benso, Fabio Beatrice, Ranieri Cancedda, Salvatore Toma

Research output: Contribution to journalArticle

Abstract

Altered expression of growth factors and growth factor receptors is frequently described in human tumors and human tumor cell lines. This further supports the hypothesis that oncogenesis is due to the subversion of mitogen-responsive pathways. The aim of this study was to investigate the expression of epidermal growth factor receptor (EGFR) and transforming growth factor α (TGFα) in 13 larynx carcinomas and 2 carcinomas of the oral cavity. We found receptor overexpression in 7 out of 15 tumors at mRNA and/or protein level but low expression in the majority of the normal adjacent tissues. TGFα was expressed only in 1 case, but no tyrosine kinase activity of the receptor was detected by antiphosphotyrosine antibody.

Original languageEnglish
Pages (from-to)189-199
Number of pages11
JournalCancer Letters
Volume65
Issue number3
DOIs
Publication statusPublished - Aug 31 1992

Keywords

  • epidermal growth factor
  • epidermal growth factor overexpression
  • larynx carcinoma
  • transforming growth factor α

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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