Expression of epidermal growth factor receptor and transforming growth factor α in human larynx carcinoma

Eddi Di Marco; Enrico Albanese; Stefano Benso; Fabio Beatrice; Ranieri Cancedda; Salvatore Toma

doi:10.1016/0304-3835(92)90231-J

Expression of epidermal growth factor receptor and transforming growth factor α in human larynx carcinoma

Eddi Di Marco, Enrico Albanese, Stefano Benso, Fabio Beatrice, Ranieri Cancedda, Salvatore Toma

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article

Abstract

Altered expression of growth factors and growth factor receptors is frequently described in human tumors and human tumor cell lines. This further supports the hypothesis that oncogenesis is due to the subversion of mitogen-responsive pathways. The aim of this study was to investigate the expression of epidermal growth factor receptor (EGFR) and transforming growth factor α (TGFα) in 13 larynx carcinomas and 2 carcinomas of the oral cavity. We found receptor overexpression in 7 out of 15 tumors at mRNA and/or protein level but low expression in the majority of the normal adjacent tissues. TGFα was expressed only in 1 case, but no tyrosine kinase activity of the receptor was detected by antiphosphotyrosine antibody.

Original language	English
Pages (from-to)	189-199
Number of pages	11
Journal	Cancer Letters
Volume	65
Issue number	3
DOIs	https://doi.org/10.1016/0304-3835(92)90231-J
Publication status	Published - Aug 31 1992

Keywords

epidermal growth factor
epidermal growth factor overexpression
larynx carcinoma
transforming growth factor α

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

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AU - Di Marco, Eddi

AU - Albanese, Enrico

AU - Benso, Stefano

AU - Beatrice, Fabio

AU - Cancedda, Ranieri

AU - Toma, Salvatore

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AB - Altered expression of growth factors and growth factor receptors is frequently described in human tumors and human tumor cell lines. This further supports the hypothesis that oncogenesis is due to the subversion of mitogen-responsive pathways. The aim of this study was to investigate the expression of epidermal growth factor receptor (EGFR) and transforming growth factor α (TGFα) in 13 larynx carcinomas and 2 carcinomas of the oral cavity. We found receptor overexpression in 7 out of 15 tumors at mRNA and/or protein level but low expression in the majority of the normal adjacent tissues. TGFα was expressed only in 1 case, but no tyrosine kinase activity of the receptor was detected by antiphosphotyrosine antibody.

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KW - transforming growth factor α

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