TY - JOUR
T1 - Expression of Erythroid Acetylcholinesterase in the K-562 Leukemia Cell Line
AU - Ajmar, Franco
AU - Garré, Cecilia
AU - Sessarego, Mario
AU - Ravazzolo, Roberto
AU - Barresi, Renata
AU - Scarrà, Giovanna Bianchi
AU - Lituania, Mario
PY - 1983/11/1
Y1 - 1983/11/1
N2 - Differentiation-dependent expression of enzyme loci was evaluated in two human leukemic cell lines, the pluripotent leukemia cell line K-562 and the promyelocytic-like cell line HL-60. Acetylcholinesterase, a marker of erythroid differentiation, was present in K-562 cells and absent in HL-60 cells. This difference between the two lines was apparently unrelated to dosage effect; other enzymes carried on trisomic chromosomes in K-562 cells did not show dosage effect. Acetylcholinesterase activity was higher in subdone K-562 (S), which shows higher expression of hemoglobin. Electrophoretic mobility of acetylcholinesterase from K-562 (S) was of fetal type.
AB - Differentiation-dependent expression of enzyme loci was evaluated in two human leukemic cell lines, the pluripotent leukemia cell line K-562 and the promyelocytic-like cell line HL-60. Acetylcholinesterase, a marker of erythroid differentiation, was present in K-562 cells and absent in HL-60 cells. This difference between the two lines was apparently unrelated to dosage effect; other enzymes carried on trisomic chromosomes in K-562 cells did not show dosage effect. Acetylcholinesterase activity was higher in subdone K-562 (S), which shows higher expression of hemoglobin. Electrophoretic mobility of acetylcholinesterase from K-562 (S) was of fetal type.
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M3 - Article
C2 - 6577951
AN - SCOPUS:0020974901
VL - 43
SP - 5560
EP - 5563
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
IS - 11
ER -