Abstract
Differentiation-dependent expression of enzyme loci was evaluated in two human leukemic cell lines, the pluripotent leukemia cell line K-562 and the promyelocytic-like cell line HL-60. Acetylcholinesterase, a marker of erythroid differentiation, was present in K-562 cells and absent in HL-60 cells. This difference between the two lines was apparently unrelated to dosage effect; other enzymes carried on trisomic chromosomes in K-562 cells did not show dosage effect. Acetylcholinesterase activity was higher in subdone K-562 (S), which shows higher expression of hemoglobin. Electrophoretic mobility of acetylcholinesterase from K-562 (S) was of fetal type.
| Original language | English |
|---|---|
| Pages (from-to) | 5560-5563 |
| Number of pages | 4 |
| Journal | Cancer Research |
| Volume | 43 |
| Issue number | 11 |
| Publication status | Published - Nov 1 1983 |
ASJC Scopus subject areas
- Cancer Research
- Oncology
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Ajmar, F., Garré, C., Sessarego, M., Ravazzolo, R., Barresi, R., Scarrà, G. B., & Lituania, M. (1983). Expression of Erythroid Acetylcholinesterase in the K-562 Leukemia Cell Line. Cancer Research, 43(11), 5560-5563.