Expression of Erythroid Acetylcholinesterase in the K-562 Leukemia Cell Line

Franco Ajmar, Cecilia Garré, Mario Sessarego, Roberto Ravazzolo, Renata Barresi, Giovanna Bianchi Scarrà, Mario Lituania

Research output: Contribution to journalArticlepeer-review


Differentiation-dependent expression of enzyme loci was evaluated in two human leukemic cell lines, the pluripotent leukemia cell line K-562 and the promyelocytic-like cell line HL-60. Acetylcholinesterase, a marker of erythroid differentiation, was present in K-562 cells and absent in HL-60 cells. This difference between the two lines was apparently unrelated to dosage effect; other enzymes carried on trisomic chromosomes in K-562 cells did not show dosage effect. Acetylcholinesterase activity was higher in subdone K-562 (S), which shows higher expression of hemoglobin. Electrophoretic mobility of acetylcholinesterase from K-562 (S) was of fetal type.

Original languageEnglish
Pages (from-to)5560-5563
Number of pages4
JournalCancer Research
Issue number11
Publication statusPublished - Nov 1 1983

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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