TY - JOUR
T1 - Expression of Fhit protein during mouse development
AU - Falvella, F. Stefania
AU - Menegola, Elena
AU - Giavini, Erminio
AU - Ottey, Michelle
AU - Fidanza, Vincenzo
AU - Croce, Carlo M.
AU - Huebner, Kay
AU - Dragani, Tommaso A.
PY - 2000/10/1
Y1 - 2000/10/1
N2 - Fhit protein has a putative tumor suppressor function in several types of human and experimental cancers. To assess whether Fhit is involved in fetal development we have examined the distribution of Fhit protein in the 12- through 16-day postcoitum mouse fetus and in postnatal day 0 mouse pups by immunocytochemistry. High levels of Fhit protein were observed in the endodermal derivatives, namely, bronchi, trachea, esophagus, stomach, and intestine, in the 12- to 16-day postcoitum mouse fetus and in the postnatal day 0 pup. Other tissues showed a more restricted pattern of Fhit protein expression. These results suggest that Fhit may play a role in the development of specific tissues during mouse development. (C) 2000 Wiley-Liss, Inc.
AB - Fhit protein has a putative tumor suppressor function in several types of human and experimental cancers. To assess whether Fhit is involved in fetal development we have examined the distribution of Fhit protein in the 12- through 16-day postcoitum mouse fetus and in postnatal day 0 mouse pups by immunocytochemistry. High levels of Fhit protein were observed in the endodermal derivatives, namely, bronchi, trachea, esophagus, stomach, and intestine, in the 12- to 16-day postcoitum mouse fetus and in the postnatal day 0 pup. Other tissues showed a more restricted pattern of Fhit protein expression. These results suggest that Fhit may play a role in the development of specific tissues during mouse development. (C) 2000 Wiley-Liss, Inc.
KW - Cartilage
KW - Development
KW - Fhit gene
KW - Lung
KW - Perichondrial region
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U2 - 10.1002/1097-0185(20001001)260:2<208::AID-AR100>3.0.CO;2-0
DO - 10.1002/1097-0185(20001001)260:2<208::AID-AR100>3.0.CO;2-0
M3 - Article
C2 - 10993957
AN - SCOPUS:0034307417
VL - 260
SP - 208
EP - 211
JO - Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology
JF - Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology
SN - 0003-276X
IS - 2
ER -