Expression of Fhit protein during mouse development

F. Stefania Falvella, Elena Menegola, Erminio Giavini, Michelle Ottey, Vincenzo Fidanza, Carlo M. Croce, Kay Huebner, Tommaso A. Dragani

Research output: Contribution to journalArticlepeer-review

Abstract

Fhit protein has a putative tumor suppressor function in several types of human and experimental cancers. To assess whether Fhit is involved in fetal development we have examined the distribution of Fhit protein in the 12- through 16-day postcoitum mouse fetus and in postnatal day 0 mouse pups by immunocytochemistry. High levels of Fhit protein were observed in the endodermal derivatives, namely, bronchi, trachea, esophagus, stomach, and intestine, in the 12- to 16-day postcoitum mouse fetus and in the postnatal day 0 pup. Other tissues showed a more restricted pattern of Fhit protein expression. These results suggest that Fhit may play a role in the development of specific tissues during mouse development. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)208-211
Number of pages4
JournalAnatomical Record
Volume260
Issue number2
DOIs
Publication statusPublished - Oct 1 2000

Keywords

  • Cartilage
  • Development
  • Fhit gene
  • Lung
  • Perichondrial region

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy

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