Expression of GATA-3 in epidermis and hair follicle: Relationship to p63

Anissa Chikh, Emre Sayan, Sebastien Thibaut, Anna Maria Lena, Sabrina DiGiorgi, Bruno A. Bernard, Gerry Melino, Eleonora Candi

Research output: Contribution to journalArticlepeer-review

Abstract

The epidermis is a multi-layered stratified epithelium continuously renewed by differentiating keratinocytes that develops by the action of p63, a member of the p53 family. The TP63 contains two promoters, resulting in the expression of different proteins, containing (TAp63) or not (ΔNp63) an amino-terminal transactivation domain, which contribution in skin formation is not fully understood. We found that p63 binds and transactivate GATA-3 promoter, which in turn transactivate IKKα, two pivotal regulators of epithelial development. Indeed, GATA-3 is a regulator of cell lineage in skin and hair follicles formation. To further study the relationship between GATA-3 and p63 isoforms here we investigated their expression during keratinocyte differentiation, in human epidermis and hair follicle.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume361
Issue number1
DOIs
Publication statusPublished - Sep 14 2007

Keywords

  • Epidermis
  • GATA-3
  • Hair follicle
  • IKKα
  • p53 family
  • p63

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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