Expression of glutamine synthetase in balloon cells: A basis of their antiepileptic role?

Anna Maria Buccoliero, Carmen Barba, Flavio Giordano, Gianna Baroni, Lorenzo Genitori, Renzo Guerrini, Gian Luigi Taddei

Research output: Contribution to journalArticlepeer-review

Abstract

Glutamine synthetase is an enzyme involved in the clearance of glutamate, the most potent excitatory neurotransmitter. We studied the immunohistochemical expression of glutamine synthetase in neocortical samples from 5 children who underwent surgery for pharmacoresistant epilepsy and a histological diagnosis of focal cortical dysplasia IIb. In all cases, balloon cells, but not dysmorphic neurons, were immunopositive for glutamine synthetase. This finding suggests that balloon cells can be involved in the neutralization of glutamate and play a protective anti-seizure role.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalClinical Neuropathology
Volume34
Issue number2
DOIs
Publication statusPublished - 2015

Keywords

  • Balloon cells
  • Epilepsy
  • Focal cortical dysplasia
  • Glutamine synthetase

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neurology

Fingerprint Dive into the research topics of 'Expression of glutamine synthetase in balloon cells: A basis of their antiepileptic role?'. Together they form a unique fingerprint.

Cite this