TY - JOUR
T1 - Expression of glutamine synthetase in balloon cells
T2 - A basis of their antiepileptic role?
AU - Buccoliero, Anna Maria
AU - Barba, Carmen
AU - Giordano, Flavio
AU - Baroni, Gianna
AU - Genitori, Lorenzo
AU - Guerrini, Renzo
AU - Taddei, Gian Luigi
PY - 2015
Y1 - 2015
N2 - Glutamine synthetase is an enzyme involved in the clearance of glutamate, the most potent excitatory neurotransmitter. We studied the immunohistochemical expression of glutamine synthetase in neocortical samples from 5 children who underwent surgery for pharmacoresistant epilepsy and a histological diagnosis of focal cortical dysplasia IIb. In all cases, balloon cells, but not dysmorphic neurons, were immunopositive for glutamine synthetase. This finding suggests that balloon cells can be involved in the neutralization of glutamate and play a protective anti-seizure role.
AB - Glutamine synthetase is an enzyme involved in the clearance of glutamate, the most potent excitatory neurotransmitter. We studied the immunohistochemical expression of glutamine synthetase in neocortical samples from 5 children who underwent surgery for pharmacoresistant epilepsy and a histological diagnosis of focal cortical dysplasia IIb. In all cases, balloon cells, but not dysmorphic neurons, were immunopositive for glutamine synthetase. This finding suggests that balloon cells can be involved in the neutralization of glutamate and play a protective anti-seizure role.
KW - Balloon cells
KW - Epilepsy
KW - Focal cortical dysplasia
KW - Glutamine synthetase
UR - http://www.scopus.com/inward/record.url?scp=84925430874&partnerID=8YFLogxK
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U2 - 10.5414/NP300794
DO - 10.5414/NP300794
M3 - Article
C2 - 25345470
AN - SCOPUS:84925430874
VL - 34
SP - 83
EP - 88
JO - Clinical Neuropathology
JF - Clinical Neuropathology
SN - 0722-5091
IS - 2
ER -