Expression of GST-mu transferase in breast cancer patients and healthy controls

A. Paradiso, M. G. Vetrugno, G. Capuano, S. Longo, L. Sibilano, F. Schittulli, M. Correale, A. Barletta, G. Pelagio, M. De Lena

Research output: Contribution to journalArticle

Abstract

The expression of glutathione S-transferase mu was measured by a qualitative immunoenzymatic assay in the blood samples of 108 women (63 breast cancer patients and 45 healthy controls) in order to analyze the relationships of GST-mu phenotype and smoking habits with tumor characteristics of breast cancer patients, such as tumor extension, nodal status, hormone receptor status and DNA content by flow cytometry. GST-mu was expressed in 53/108 (49%) of cases without any significant difference between healthy or neoplastic subjects, smokers or non-smokers, pre or post-menopausal, younger or older subjects. Moreover, the percentages of the GST-mu phenotype did not differ significantly in patients with different ER and PgR tumor status, tumor extension or nodal status. By contrast, aneuploid DNA tumor content was shown to be significantly associated with GST-mu expression (24% and 76% GST-mu positive, respectively, in diploid and aneuploid cases; p <0.003). The biological meaning of this association remains to be interpreted.

Original languageEnglish
Pages (from-to)219-223
Number of pages5
JournalInternational Journal of Biological Markers
Volume9
Issue number4
Publication statusPublished - 1994

Fingerprint

Transferases
Tumors
Breast Neoplasms
Aneuploidy
Neoplasms
Glutathione Transferase
Phenotype
Flow cytometry
DNA
Diploidy
Habits
Assays
Flow Cytometry
Blood
Smoking
Association reactions
Hormones

Keywords

  • breast cancer
  • glutathione S-transferase
  • tumor marker

ASJC Scopus subject areas

  • Biochemistry
  • Immunology

Cite this

Paradiso, A., Vetrugno, M. G., Capuano, G., Longo, S., Sibilano, L., Schittulli, F., ... De Lena, M. (1994). Expression of GST-mu transferase in breast cancer patients and healthy controls. International Journal of Biological Markers, 9(4), 219-223.

Expression of GST-mu transferase in breast cancer patients and healthy controls. / Paradiso, A.; Vetrugno, M. G.; Capuano, G.; Longo, S.; Sibilano, L.; Schittulli, F.; Correale, M.; Barletta, A.; Pelagio, G.; De Lena, M.

In: International Journal of Biological Markers, Vol. 9, No. 4, 1994, p. 219-223.

Research output: Contribution to journalArticle

Paradiso, A, Vetrugno, MG, Capuano, G, Longo, S, Sibilano, L, Schittulli, F, Correale, M, Barletta, A, Pelagio, G & De Lena, M 1994, 'Expression of GST-mu transferase in breast cancer patients and healthy controls', International Journal of Biological Markers, vol. 9, no. 4, pp. 219-223.
Paradiso A, Vetrugno MG, Capuano G, Longo S, Sibilano L, Schittulli F et al. Expression of GST-mu transferase in breast cancer patients and healthy controls. International Journal of Biological Markers. 1994;9(4):219-223.
Paradiso, A. ; Vetrugno, M. G. ; Capuano, G. ; Longo, S. ; Sibilano, L. ; Schittulli, F. ; Correale, M. ; Barletta, A. ; Pelagio, G. ; De Lena, M. / Expression of GST-mu transferase in breast cancer patients and healthy controls. In: International Journal of Biological Markers. 1994 ; Vol. 9, No. 4. pp. 219-223.
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