Expression of HECA-452 antigen correlates with disease relapse in mycosis fungoides

Rossella Di Trolio, Giuseppe Di Lorenzo, Alessandro Iacono, Alessandra Filosa, Mario Delfino, Francesco Paolo D'Armiento

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To determine the expression of HECA-452 epitope in mycosis fungoides (MF), assess whether its expression increases in relapsed MF compared with nonrelapsed MF and determine the potential prognostic relevance of HECA-452 expression. STUDY DESIGN: HECA-452 expression was evaluated by immunohistochemistry in a consecutive series of 20 MF. In all patients we evaluated the disease-free survival rate according to HECA-452 expression in a univariate analysis. RESULTS: We found a low expression in 5 MF (25%), a moderate expression in 8 MF (40%) and a high expression in 7 MF (35%) in the intraepidermal area. All patients were disease-free after appropriate therapy. Four of 20 patients (20%) relapsed within 2 years. HECA-452 expression significantly correlated with disease relapse in these patients. In fact, among the 7 patients whose lesions had a high expression, 4 had a disease recurrence (57%), whereas 0 of 13 (0%) with a low or moderate expression relapsed (p

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalAnalytical and Quantitative Cytology and Histology
Volume30
Issue number4
Publication statusPublished - Aug 2008

Keywords

  • Cutaneous t-cell lymphoma
  • Cutaneous-associated lymphocytes antigen
  • HECA-452
  • Mycosis fungoides
  • Prognostic factor

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Cell Biology

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