Abstract
OBJECTIVE: To determine the expression of HECA-452 epitope in mycosis fungoides (MF), assess whether its expression increases in relapsed MF compared with nonrelapsed MF and determine the potential prognostic relevance of HECA-452 expression. STUDY DESIGN: HECA-452 expression was evaluated by immunohistochemistry in a consecutive series of 20 MF. In all patients we evaluated the disease-free survival rate according to HECA-452 expression in a univariate analysis. RESULTS: We found a low expression in 5 MF (25%), a moderate expression in 8 MF (40%) and a high expression in 7 MF (35%) in the intraepidermal area. All patients were disease-free after appropriate therapy. Four of 20 patients (20%) relapsed within 2 years. HECA-452 expression significantly correlated with disease relapse in these patients. In fact, among the 7 patients whose lesions had a high expression, 4 had a disease recurrence (57%), whereas 0 of 13 (0%) with a low or moderate expression relapsed (p
| Original language | English |
|---|---|
| Pages (from-to) | 203-208 |
| Number of pages | 6 |
| Journal | Analytical and Quantitative Cytology and Histology |
| Volume | 30 |
| Issue number | 4 |
| Publication status | Published - Aug 2008 |
Keywords
- Cutaneous t-cell lymphoma
- Cutaneous-associated lymphocytes antigen
- HECA-452
- Mycosis fungoides
- Prognostic factor
ASJC Scopus subject areas
- Anatomy
- Histology
- Cell Biology