TY - JOUR
T1 - Expression of HER/erbB family of receptor tyrosine kinases and induction of differentiation by glial growth factor 2 in human rhabdomyosarcoma cells
AU - Ricci, C.
AU - Landuzzi, L.
AU - Rossi, I.
AU - De Giovanni, C.
AU - Nicoletti, G.
AU - Astolfi, A.
AU - Pupa, S.
AU - Menard, S.
AU - Scotlandi, K.
AU - Nanni, P.
AU - Loluni, Pier Luigi
PY - 2000
Y1 - 2000
N2 - Five human rhabdomyosarcoma cell lines were used to investigate the surface expression of HER/erbB receptors, particularly of HER-2, HER-3 and HER-4, by flow cytometry. HER-2 was expressed in 3/5 rhabdomyosarcoma cell lines. HER-3 was expressed in all rhabdomyosarcoma cell lines. None of the rhabdomyosarcoma cell lines investigated showed HER-4 surface expression. To study the biological activity of HER/erbB receptors in rhabdomyosarcomas, cells were cultured in the presence of glial growth factor 2 (GGF2), a specific ligand of HER-3 that is able to stimulate myogenesis in normal myoblasts. In 3 of 3 human rhabdomyosarcoma cell lines positive for both HER- 2 and HER-3 receptors, the treatment with GGF-2 induced a significant increase in myogenic differentiation. (C) 2000 Wiley-Liss, Inc.
AB - Five human rhabdomyosarcoma cell lines were used to investigate the surface expression of HER/erbB receptors, particularly of HER-2, HER-3 and HER-4, by flow cytometry. HER-2 was expressed in 3/5 rhabdomyosarcoma cell lines. HER-3 was expressed in all rhabdomyosarcoma cell lines. None of the rhabdomyosarcoma cell lines investigated showed HER-4 surface expression. To study the biological activity of HER/erbB receptors in rhabdomyosarcomas, cells were cultured in the presence of glial growth factor 2 (GGF2), a specific ligand of HER-3 that is able to stimulate myogenesis in normal myoblasts. In 3 of 3 human rhabdomyosarcoma cell lines positive for both HER- 2 and HER-3 receptors, the treatment with GGF-2 induced a significant increase in myogenic differentiation. (C) 2000 Wiley-Liss, Inc.
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U2 - 10.1002/1097-0215(20000701)87:1<29::AID-IJC5>3.0.CO;2-J
DO - 10.1002/1097-0215(20000701)87:1<29::AID-IJC5>3.0.CO;2-J
M3 - Article
C2 - 10861449
AN - SCOPUS:0034045165
VL - 87
SP - 29
EP - 36
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 1
ER -