Expression of HLA class II determinants by normal and chronic myeloid leukemia progenitors

Wanda Piacibello, Massimo Aglietta, Alessandra Stacchini, Patrizia Spinelli, Laura Salvetti, Simonetta Kerim, Fabio Malavasi, Vittorio Infelise, Luigi Resegotti, Felice Gavosto

Research output: Contribution to journalArticlepeer-review

Abstract

It has been suggested that the expression of some HLA class II antigens, derived from three loci (DR, DP, DQ) is important in the regulation of both the immune response and the response of haemopoietic progenitors to regulation factors, such as acidic isoferritins (AIF), as well as in the interaction between T lymphocytes and erythroid progenitors (BFU-E). Changes in the expression of class II antigens have been reported on the surface of granulo-monocyte progenitors in chronic myeloid leukemia (CML) and correlated to the abnormal proliferation of such cells. In this study, monoclonal antibodies against DR and DQ monomorphic determinants were used to investigate the expression of these antigens on the surface of normal and CML bone marrow and peripheral blood BFU-E by means of complement mediated cytotoxicity. It was found that most normal and leukemic BFU-E express DR antigens. Antigen density tends to be greater on marrow as opposed to peripheral precursors. In addition, leukemic BFU-E are more sensitive to cytolytic treatment than their normal counterparts. Normal BFU-E do not express detectable amounts of DQ antigens, whereas these are present on a proportion of leukemic BFU-E.

Original languageEnglish
Pages (from-to)285-290
Number of pages6
JournalLeukemia Research
Volume11
Issue number3
DOIs
Publication statusPublished - 1987

Keywords

  • chronic myeloid leukemia
  • erythropoiesis
  • HLA class II antigens

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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