Expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in undifferentiated nasopharyngeal carcinoma (lymphoepithelioma) and in malignant epithelial tumors

Luigi P. Ruco, Antonella Stoppacciaro, Stefania Uccini, Ferruccio Breviario, Elisabetta Dejana, Andrea Gallo, Marco De Vincentiis, Stefano Pileri, John M. Nicholls, Carlo D. Baroni

Research output: Contribution to journalArticlepeer-review

Abstract

Immunoreactivity for intercellular adhesion molecule-1 (ICAM-1) and for vascular cell adhesion molecule-1 (VCAM-1), two adhesion molecules of the immunoglobulin (Ig) superfamily, was tested and measured on tissue sections from 16 undifferentiated nasopharyngeal carcinomas (U-NPC), 12 keratinizing squamous cell carcinomas (SCCs) of the head and neck region, and 54 malignant epithelial tumors of various origin. Neoplastic cells of all cases of U-NPC were diffusely and intensely stained for ICAM-1 and VCAM-1. Moreover, ICAM-1 messenger RNA (mRNA) and VCAM-1 mRNA were detected by Northern blot analysis of RNA extracts from two tumors. In the other epithelial tumors focal or diffuse staining for ICAM-1 was observed in 40 cases (66%), whereas reactivity for VCAM-1 was detected in a single case of metastatic undifferentiated carcinoma of unknown origin. The biopsy specimens of U-NPC showed variable infiltration by leukocytes, which were positive for the intergrins lymphocyte function antigen-1 (LFA-1) and alpha-4/beta-1, the corresponding ligands for ICAM-1 and VCAM-1. The possibility that ICAM-1 and VCAM-1 on neoplastic cells may favor the intratumoral recruitment of leukocytes in a way similar to that occurring in crypt epithelium of the palatine tonsil is discussed.

Original languageEnglish
Pages (from-to)924-928
Number of pages5
JournalHuman Pathology
Volume25
Issue number9
DOIs
Publication statusPublished - 1994

Keywords

  • integrins
  • intercellular adhesion molecule-1
  • lymphoepithelioma
  • nasopharyngeal carcinoma
  • vascular cell adhesion molecule-1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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