Espressione dell'antigene carboidratico Lewis nei tumori umani.

Translated title of the contribution: Expression of Lewis carbohydrate antigen in human tumors

Vincenzo D'Alessandro, Daniela Terracciano, Enrico Di Salvo, Andrea Renda, Mario Luigi Santangelo, Angelina Di Carlo, Angela Mariano, Vincenzo Macchia

Research output: Contribution to journalArticle

Abstract

In this study we show, by immunoblotting, that Mab B3, a newly isolated monoclonal antibody, reacts with a variety of glycoproteins with different molecular weights expressed in gastric, pancreatic and colorectal cancers. The reactivity pattern differed in cancers arising in different tissues, though no correlation was observed with the histopathological characteristics of the lesions analysed. MAb B3 does not react with liver, brain or kidney cancers and has a limited reactivity with lung cancers but reacts very strongly with metastatic lesions. Because of the limited reactivity of this antibody with normal tissues, MAb B3 genetically fused with toxin in the form of a recombinant immunotoxin may be useful in treating certain kinds of cancer such as metastatic lesions. However, until current trials are completed, we will not know whether this immunotoxin will be helpful in cancer treatment.

Original languageItalian
Pages (from-to)355-361
Number of pages7
JournalChirurgia Italiana
Volume54
Issue number3
Publication statusPublished - May 2002

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Immunotoxins
Carbohydrates
Antigens
Neoplasms
Kidney Neoplasms
Liver Neoplasms
Pancreatic Neoplasms
Immunoblotting
Brain Neoplasms
Stomach Neoplasms
Colorectal Neoplasms
Lung Neoplasms
Glycoproteins
Molecular Weight
Monoclonal Antibodies
Antibodies

ASJC Scopus subject areas

  • Surgery

Cite this

D'Alessandro, V., Terracciano, D., Di Salvo, E., Renda, A., Santangelo, M. L., Di Carlo, A., ... Macchia, V. (2002). Espressione dell'antigene carboidratico Lewis nei tumori umani. Chirurgia Italiana, 54(3), 355-361.

Espressione dell'antigene carboidratico Lewis nei tumori umani. / D'Alessandro, Vincenzo; Terracciano, Daniela; Di Salvo, Enrico; Renda, Andrea; Santangelo, Mario Luigi; Di Carlo, Angelina; Mariano, Angela; Macchia, Vincenzo.

In: Chirurgia Italiana, Vol. 54, No. 3, 05.2002, p. 355-361.

Research output: Contribution to journalArticle

D'Alessandro, V, Terracciano, D, Di Salvo, E, Renda, A, Santangelo, ML, Di Carlo, A, Mariano, A & Macchia, V 2002, 'Espressione dell'antigene carboidratico Lewis nei tumori umani.', Chirurgia Italiana, vol. 54, no. 3, pp. 355-361.
D'Alessandro V, Terracciano D, Di Salvo E, Renda A, Santangelo ML, Di Carlo A et al. Espressione dell'antigene carboidratico Lewis nei tumori umani. Chirurgia Italiana. 2002 May;54(3):355-361.
D'Alessandro, Vincenzo ; Terracciano, Daniela ; Di Salvo, Enrico ; Renda, Andrea ; Santangelo, Mario Luigi ; Di Carlo, Angelina ; Mariano, Angela ; Macchia, Vincenzo. / Espressione dell'antigene carboidratico Lewis nei tumori umani. In: Chirurgia Italiana. 2002 ; Vol. 54, No. 3. pp. 355-361.
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