Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia

Antonio Chiaretti, Antonio Ruggiero, Paola Coccia, Alessia Antonelli, Filomena Pierri, Giovanni Barone, Giorgio Attinà, Laura Iuvone, Palma Maurizi, Riccardo Riccardi

Research output: Contribution to journalArticlepeer-review


Brain damage related to intrathecal methotrexate in children with acute lymphoblastic leukemia (ALL) is still unclear. Neuroinflammatory mechanisms and intracerebral production of specific biomarkers, play a key role in determining neuroprotective mechanisms after brain injury. To determine whether the CSF concentrations of neuron-specific enolase (NSE), neurotrophic factors and doublecortin (DCX) are influenced by repeated intrathecal methotrexate administrations, we prospectively collected CSF samples from 10 children with ALL and 10 controls. Our results showed an increased expression of the liquoral markers. This up-regulation could be interpreted as a neuroprotective response of the brain against the neuronal damages induced by MTX.

Original languageEnglish
Pages (from-to)1467-1471
Number of pages5
JournalLeukemia Research
Issue number11
Publication statusPublished - Nov 2011


  • Acute lymphoblastic leukemia
  • Children
  • Intrathecal methotrexate
  • Neurotoxicity
  • Neurotrophic factor

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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