Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia

Antonio Chiaretti, Antonio Ruggiero, Paola Coccia, Alessia Antonelli, Filomena Pierri, Giovanni Barone, Giorgio Attinà, Laura Iuvone, Palma Maurizi, Riccardo Riccardi

Research output: Contribution to journalArticle

Abstract

Brain damage related to intrathecal methotrexate in children with acute lymphoblastic leukemia (ALL) is still unclear. Neuroinflammatory mechanisms and intracerebral production of specific biomarkers, play a key role in determining neuroprotective mechanisms after brain injury. To determine whether the CSF concentrations of neuron-specific enolase (NSE), neurotrophic factors and doublecortin (DCX) are influenced by repeated intrathecal methotrexate administrations, we prospectively collected CSF samples from 10 children with ALL and 10 controls. Our results showed an increased expression of the liquoral markers. This up-regulation could be interpreted as a neuroprotective response of the brain against the neuronal damages induced by MTX.

Original languageEnglish
Pages (from-to)1467-1471
Number of pages5
JournalLeukemia Research
Volume35
Issue number11
DOIs
Publication statusPublished - Nov 2011

Fingerprint

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Methotrexate
Phosphopyruvate Hydratase
Nerve Growth Factors
Brain
Brain Injuries
Up-Regulation
Biomarkers
Neuroprotection

Keywords

  • Acute lymphoblastic leukemia
  • Children
  • Intrathecal methotrexate
  • Neurotoxicity
  • Neurotrophic factor

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Chiaretti, A., Ruggiero, A., Coccia, P., Antonelli, A., Pierri, F., Barone, G., ... Riccardi, R. (2011). Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia. Leukemia Research, 35(11), 1467-1471. https://doi.org/10.1016/j.leukres.2011.07.025

Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia. / Chiaretti, Antonio; Ruggiero, Antonio; Coccia, Paola; Antonelli, Alessia; Pierri, Filomena; Barone, Giovanni; Attinà, Giorgio; Iuvone, Laura; Maurizi, Palma; Riccardi, Riccardo.

In: Leukemia Research, Vol. 35, No. 11, 11.2011, p. 1467-1471.

Research output: Contribution to journalArticle

Chiaretti, A, Ruggiero, A, Coccia, P, Antonelli, A, Pierri, F, Barone, G, Attinà, G, Iuvone, L, Maurizi, P & Riccardi, R 2011, 'Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia', Leukemia Research, vol. 35, no. 11, pp. 1467-1471. https://doi.org/10.1016/j.leukres.2011.07.025
Chiaretti A, Ruggiero A, Coccia P, Antonelli A, Pierri F, Barone G et al. Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia. Leukemia Research. 2011 Nov;35(11):1467-1471. https://doi.org/10.1016/j.leukres.2011.07.025
Chiaretti, Antonio ; Ruggiero, Antonio ; Coccia, Paola ; Antonelli, Alessia ; Pierri, Filomena ; Barone, Giovanni ; Attinà, Giorgio ; Iuvone, Laura ; Maurizi, Palma ; Riccardi, Riccardo. / Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia. In: Leukemia Research. 2011 ; Vol. 35, No. 11. pp. 1467-1471.
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