Abstract
Brain damage related to intrathecal methotrexate in children with acute lymphoblastic leukemia (ALL) is still unclear. Neuroinflammatory mechanisms and intracerebral production of specific biomarkers, play a key role in determining neuroprotective mechanisms after brain injury. To determine whether the CSF concentrations of neuron-specific enolase (NSE), neurotrophic factors and doublecortin (DCX) are influenced by repeated intrathecal methotrexate administrations, we prospectively collected CSF samples from 10 children with ALL and 10 controls. Our results showed an increased expression of the liquoral markers. This up-regulation could be interpreted as a neuroprotective response of the brain against the neuronal damages induced by MTX.
Original language | English |
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Pages (from-to) | 1467-1471 |
Number of pages | 5 |
Journal | Leukemia Research |
Volume | 35 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2011 |
Keywords
- Acute lymphoblastic leukemia
- Children
- Intrathecal methotrexate
- Neurotoxicity
- Neurotrophic factor
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology