Abstract
Brain damage related to intrathecal methotrexate in children with acute lymphoblastic leukemia (ALL) is still unclear. Neuroinflammatory mechanisms and intracerebral production of specific biomarkers, play a key role in determining neuroprotective mechanisms after brain injury. To determine whether the CSF concentrations of neuron-specific enolase (NSE), neurotrophic factors and doublecortin (DCX) are influenced by repeated intrathecal methotrexate administrations, we prospectively collected CSF samples from 10 children with ALL and 10 controls. Our results showed an increased expression of the liquoral markers. This up-regulation could be interpreted as a neuroprotective response of the brain against the neuronal damages induced by MTX.
| Original language | English |
|---|---|
| Pages (from-to) | 1467-1471 |
| Number of pages | 5 |
| Journal | Leukemia Research |
| Volume | 35 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2011 |
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Keywords
- Acute lymphoblastic leukemia
- Children
- Intrathecal methotrexate
- Neurotoxicity
- Neurotrophic factor
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia. / Chiaretti, Antonio; Ruggiero, Antonio; Coccia, Paola; Antonelli, Alessia; Pierri, Filomena; Barone, Giovanni; Attinà, Giorgio; Iuvone, Laura; Maurizi, Palma; Riccardi, Riccardo.
In: Leukemia Research, Vol. 35, No. 11, 11.2011, p. 1467-1471.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia
AU - Chiaretti, Antonio
AU - Ruggiero, Antonio
AU - Coccia, Paola
AU - Antonelli, Alessia
AU - Pierri, Filomena
AU - Barone, Giovanni
AU - Attinà, Giorgio
AU - Iuvone, Laura
AU - Maurizi, Palma
AU - Riccardi, Riccardo
PY - 2011/11
Y1 - 2011/11
N2 - Brain damage related to intrathecal methotrexate in children with acute lymphoblastic leukemia (ALL) is still unclear. Neuroinflammatory mechanisms and intracerebral production of specific biomarkers, play a key role in determining neuroprotective mechanisms after brain injury. To determine whether the CSF concentrations of neuron-specific enolase (NSE), neurotrophic factors and doublecortin (DCX) are influenced by repeated intrathecal methotrexate administrations, we prospectively collected CSF samples from 10 children with ALL and 10 controls. Our results showed an increased expression of the liquoral markers. This up-regulation could be interpreted as a neuroprotective response of the brain against the neuronal damages induced by MTX.
AB - Brain damage related to intrathecal methotrexate in children with acute lymphoblastic leukemia (ALL) is still unclear. Neuroinflammatory mechanisms and intracerebral production of specific biomarkers, play a key role in determining neuroprotective mechanisms after brain injury. To determine whether the CSF concentrations of neuron-specific enolase (NSE), neurotrophic factors and doublecortin (DCX) are influenced by repeated intrathecal methotrexate administrations, we prospectively collected CSF samples from 10 children with ALL and 10 controls. Our results showed an increased expression of the liquoral markers. This up-regulation could be interpreted as a neuroprotective response of the brain against the neuronal damages induced by MTX.
KW - Acute lymphoblastic leukemia
KW - Children
KW - Intrathecal methotrexate
KW - Neurotoxicity
KW - Neurotrophic factor
UR - http://www.scopus.com/inward/record.url?scp=80053970784&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053970784&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2011.07.025
DO - 10.1016/j.leukres.2011.07.025
M3 - Article
C2 - 21846577
AN - SCOPUS:80053970784
VL - 35
SP - 1467
EP - 1471
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 11
ER -