Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia

Antonio Chiaretti; Antonio Ruggiero; Paola Coccia; Alessia Antonelli; Filomena Pierri; Giovanni Barone; Giorgio Attinà; Laura Iuvone; Palma Maurizi; Riccardo Riccardi

doi:10.1016/j.leukres.2011.07.025

Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia

Antonio Chiaretti, Antonio Ruggiero, Paola Coccia, Alessia Antonelli, Filomena Pierri, Giovanni Barone, Giorgio Attinà, Laura Iuvone, Palma Maurizi, Riccardo Riccardi

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Brain damage related to intrathecal methotrexate in children with acute lymphoblastic leukemia (ALL) is still unclear. Neuroinflammatory mechanisms and intracerebral production of specific biomarkers, play a key role in determining neuroprotective mechanisms after brain injury. To determine whether the CSF concentrations of neuron-specific enolase (NSE), neurotrophic factors and doublecortin (DCX) are influenced by repeated intrathecal methotrexate administrations, we prospectively collected CSF samples from 10 children with ALL and 10 controls. Our results showed an increased expression of the liquoral markers. This up-regulation could be interpreted as a neuroprotective response of the brain against the neuronal damages induced by MTX.

Original language	English
Pages (from-to)	1467-1471
Number of pages	5
Journal	Leukemia Research
Volume	35
Issue number	11
DOIs	https://doi.org/10.1016/j.leukres.2011.07.025
Publication status	Published - Nov 2011

Keywords

Acute lymphoblastic leukemia
Children
Intrathecal methotrexate
Neurotoxicity
Neurotrophic factor

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology

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Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia. / Chiaretti, Antonio; Ruggiero, Antonio; Coccia, Paola; Antonelli, Alessia; Pierri, Filomena; Barone, Giovanni; Attinà, Giorgio; Iuvone, Laura; Maurizi, Palma; Riccardi, Riccardo.

In: Leukemia Research, Vol. 35, No. 11, 11.2011, p. 1467-1471.

Research output: Contribution to journal › Article › peer-review

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abstract = "Brain damage related to intrathecal methotrexate in children with acute lymphoblastic leukemia (ALL) is still unclear. Neuroinflammatory mechanisms and intracerebral production of specific biomarkers, play a key role in determining neuroprotective mechanisms after brain injury. To determine whether the CSF concentrations of neuron-specific enolase (NSE), neurotrophic factors and doublecortin (DCX) are influenced by repeated intrathecal methotrexate administrations, we prospectively collected CSF samples from 10 children with ALL and 10 controls. Our results showed an increased expression of the liquoral markers. This up-regulation could be interpreted as a neuroprotective response of the brain against the neuronal damages induced by MTX.",

keywords = "Acute lymphoblastic leukemia, Children, Intrathecal methotrexate, Neurotoxicity, Neurotrophic factor",

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AU - Chiaretti, Antonio

AU - Ruggiero, Antonio

AU - Coccia, Paola

AU - Antonelli, Alessia

AU - Pierri, Filomena

AU - Barone, Giovanni

AU - Attinà, Giorgio

AU - Iuvone, Laura

AU - Maurizi, Palma

AU - Riccardi, Riccardo

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AB - Brain damage related to intrathecal methotrexate in children with acute lymphoblastic leukemia (ALL) is still unclear. Neuroinflammatory mechanisms and intracerebral production of specific biomarkers, play a key role in determining neuroprotective mechanisms after brain injury. To determine whether the CSF concentrations of neuron-specific enolase (NSE), neurotrophic factors and doublecortin (DCX) are influenced by repeated intrathecal methotrexate administrations, we prospectively collected CSF samples from 10 children with ALL and 10 controls. Our results showed an increased expression of the liquoral markers. This up-regulation could be interpreted as a neuroprotective response of the brain against the neuronal damages induced by MTX.

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