Expression of MDR1 and GST-π in human soft tissue sarcomas: Relation to drug resistance and biological aggressiveness

G. Toffoli, S. Frustaci, L. Tumiotto, R. Talamini, F. Gherlinzoni, P. Picci, M. Boiocchi

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Human soft tissue sarcomas (HSTS) in adults are a family of mesenchymal tumors characterized by high biological aggressiveness and general refractoriness to chemotherapy. A series of 36 HSTS, 24 untreated and 12 homogeneously treated with a presurgical chemotherapeutic regimen consisting of doxorubicin (intra-arterial) and iphosphamide (intra-vein), was analyzed for expression of MDR1 and the glutatione-S-transferase-π (GST-π) gene in order to identify molecular phenomena which may be implicated in the chemoresistance displayed by these tumors. The MDR1 gene was expressed in a greater percentage of drug-treated tumors and at higher levels than in untreated ones. By contrast, chemotherapeutic treatment has no effect on GST-π mRNA expression. The GST-π expression level (EL) was much higher in the HSTS with biologically aggressive features. In fact, significant correlations were observed between GST-π and histologic grade (p = 0.01); aneuploidy (p <0.01); and histone H3 EL (p = 0.01), suggesting a possible causal relationsinp between GST-π activity and biological aggressiveness in HSTS.

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalAnnals of Oncology
Issue number1
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Public Health, Environmental and Occupational Health
  • Neuropsychology and Physiological Psychology
  • Hematology


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