Expression of metalloproteinases MMP-2 and MMP-9 in sentinel lymph node and serum of patients with metastatic and non-metastatic breast cancer

Antonella Daniele, A. F. Zito, G. Giannelli, R. Divella, M. Asselti, A. Mazzocca, A. Paradiso, M. Quaranta

Research output: Contribution to journalArticle

Abstract

The objective of this study was to evaluate the expression of MMP-2 and MMP-9 in sentinel lymph node and serum of breast cancer patients in order to evaluate their clinical significance and usefulness as diagnostic tumour markers. Expression of MMP-2 and MMP-9 was performed on sentinel lymph node by immunohistochemistry while gelatine zymography was used to determinate the serum expression. The association of gelatinases with clinicopathological features, were analysed. Metastatic and non-metastatic breast cancer patients and 34 healthy women were involved. Gelatinases expression were significantly higher in metastatic breast cancer in comparison to non-metastatic cancer and the control group both in the sentinel lymph node and serum. Results showed a statistically significant correlation between MMP-2 or MMP-9 and cancer familiality, MMP-9 and CA 153 levels, and MMP-9 and grading. This study suggests a clinical utility of these proteolytic markers in malignant tumour, growth, invasion and metastasis in breast cancer.

Original languageEnglish
Pages (from-to)3521-3527
Number of pages7
JournalAnticancer Research
Volume30
Issue number9
Publication statusPublished - 2010

Keywords

  • Breast cancer
  • Metastasis
  • MMP-2
  • MMP-9
  • Sentinel lymph node

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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    Daniele, A., Zito, A. F., Giannelli, G., Divella, R., Asselti, M., Mazzocca, A., Paradiso, A., & Quaranta, M. (2010). Expression of metalloproteinases MMP-2 and MMP-9 in sentinel lymph node and serum of patients with metastatic and non-metastatic breast cancer. Anticancer Research, 30(9), 3521-3527.