Expression of mouse and human fibronectin in mouse-human somatic cell hybrids

Luciano Zardi, Barbara Carnemolla, Carlo M. Croce

Research output: Contribution to journalArticlepeer-review

Abstract

Using antisera to the human and mouse fibronectin (Large External Transformation Sensitive (LETS) protein), we studied the expression of mouse and human fibronectin in mouse-human somatic cell hybrids segregating either human or mouse chromosomes. The results of this study show that, in such somatic cell hybrids, mouse and human fibronectin are coexpressed. In addition, activation of the synthesis of mouse fibronectin was observed in somatic cell hybrids between mouse peritoneal macrophages, which do not produce detectable amounts of fibronectin, and either SV40-transformed human cells or cells derived from a human fibrosarcoma.

Original languageEnglish
Pages (from-to)435-438
Number of pages4
JournalExperimental Cell Research
Volume118
Issue number2
DOIs
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Cell Biology

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