Expression of p63 is the sole independent marker of aggressiveness in localised (stage I-II) Merkel cell carcinomas

Sofia Asioli, Alberto Righi, Dario De Biase, Luca Morandi, Virginia Caliendo, Franco Picciotto, Giuseppe MacRipò, Francesca Maletta, Ludovica Verdun Di Cantogno, Luigi Chiusa, Vincenzo Eusebi, Gianni Bussolati

Research output: Contribution to journalArticlepeer-review

Abstract

Merkel cell carcinoma of the skin is a malignant neuroendocrine tumour, whose prognostic criteria are a matter of dispute. Specifically, no predictor is presently available in stage I-II tumours. We collected clinical and follow-up data from 70 Merkel cell carcinomas of the skin. The same cases were studied for p63 expression by immunohistochemistry, by reverse-transcription PCR (RT-PCR) and TP63 gene status by FISH and for presence of Merkel cell polyomavirus by PCR. Stage emerged as a significant prognostic parameter (P

Original languageEnglish
Pages (from-to)1451-1461
Number of pages11
JournalModern Pathology
Volume24
Issue number11
DOIs
Publication statusPublished - Nov 2011

Keywords

  • FISH
  • Merkel cell carcinoma
  • p63 isoforms
  • prognosis
  • stage

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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