Expression of proteins involved in DNA damage response in familial and sporadic breast cancer patients

Giulia Partipilo, Giovanni Simone, Anna Scattone, Emanuela Scarpi, Amalia Azzariti, Anita Mangia

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Understanding the expression of proteins involved in DNA damage response could improve knowledge of the pathways that contribute to familial and sporadic breast cancer (BC). We aimed to assess the different roles of BRCA1, poly(ADP-ribose) polymerase-1 (PARP1), BRCT-repeat inhibitor of hTERT expression (BRIT1) and novel SWItch 5 (SWI5) expression in 130 sporadic and 73 familial BC samples, by immunohistochemistry. In the sporadic group, negative nuclear BRCA1 (nBRCA1) expression was associated with positive PgR (p=0.037). Negative association was found between nBRCA1 expression and HER2 (p=0.001). In the familial group, nBRCA1 expression was associated with ER (p=0.002). Reduced nBRCA1 expression was associated with higher histological grade and positive Ki67 both in sporadic (p=0.0010, p=0.047) and familial groups (p

Original languageEnglish
Pages (from-to)110-120
Number of pages11
JournalInternational Journal of Cancer
Volume138
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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DNA Damage
Proteins
Immunohistochemistry
Familial Breast Cancer
Poly (ADP-Ribose) Polymerase-1

Keywords

  • BRCA1
  • BRIT1
  • immunohistochemistry
  • PARP1
  • sporadic and familial breast cancers

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Expression of proteins involved in DNA damage response in familial and sporadic breast cancer patients. / Partipilo, Giulia; Simone, Giovanni; Scattone, Anna; Scarpi, Emanuela; Azzariti, Amalia; Mangia, Anita.

In: International Journal of Cancer, Vol. 138, No. 1, 01.01.2016, p. 110-120.

Research output: Contribution to journalArticle

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