Expression of retroviral sequences and oncogenes in murine hepatocellular tumors

T. A. Dragani, G. Manenti, G. della Porta, S. Gattoni-Celli, I. B. Weinstein

Research output: Contribution to journalArticle

Abstract

The expression of endogenous retroviral sequences and of three cellular oncogenes was examined in three hepatocellular adenomas and in four carcinomas induced in male C57BL/5JDp x C3Hf/Dp F1 (hereafter called B6C3F1) mice by a single dose of nitrosodiethylamine, in five carcinomas that arose spontaneously in male C3Hf mice, and in the livers of normal age-matched control mice. In all of these adenomas and carcinomas, there was increased expression of Moloney murine leukemia virus- and intracisternal A particle-related sequences. The retrovirus-like VL30 sequence was expressed at significant levels in the normal liver of these mice and increased expression of this sequence was found in only 4 of the 12 tumors examined. Expression of endogenous mouse mammary tumor virus-related sequences was not detected in the normal livers or in any of the liver tumors. With respect to cellular oncogenes, increased expression of c-myc was seen in all of the B6C3F1 tumors. Two of five normal liver samples and all of the C3Hf mice displayed significant expression of c-myc. There was a light increase in expression of c-Ha-ras in some of the tumors. Increased expression of c-fos was found in only 1 of the 12 tumors. Taken together, these studies indicate that both carcinogen-induced and spontaneous liver tumor formation in mice is associated with abnormalities in the expression of endogenous retrovirus-related DNA sequences and also specific cellular oncogenes.

Original languageEnglish
Pages (from-to)1915-1919
Number of pages5
JournalCancer Research
Volume46
Issue number4 II
Publication statusPublished - 1986

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Oncogenes
Liver
Neoplasms
Carcinoma
Liver Cell Adenoma
Moloney murine leukemia virus
Endogenous Retroviruses
Mouse mammary tumor virus
Diethylnitrosamine
Retroviridae
Carcinogens
Adenoma
Light

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Dragani, T. A., Manenti, G., della Porta, G., Gattoni-Celli, S., & Weinstein, I. B. (1986). Expression of retroviral sequences and oncogenes in murine hepatocellular tumors. Cancer Research, 46(4 II), 1915-1919.

Expression of retroviral sequences and oncogenes in murine hepatocellular tumors. / Dragani, T. A.; Manenti, G.; della Porta, G.; Gattoni-Celli, S.; Weinstein, I. B.

In: Cancer Research, Vol. 46, No. 4 II, 1986, p. 1915-1919.

Research output: Contribution to journalArticle

Dragani, TA, Manenti, G, della Porta, G, Gattoni-Celli, S & Weinstein, IB 1986, 'Expression of retroviral sequences and oncogenes in murine hepatocellular tumors', Cancer Research, vol. 46, no. 4 II, pp. 1915-1919.
Dragani, T. A. ; Manenti, G. ; della Porta, G. ; Gattoni-Celli, S. ; Weinstein, I. B. / Expression of retroviral sequences and oncogenes in murine hepatocellular tumors. In: Cancer Research. 1986 ; Vol. 46, No. 4 II. pp. 1915-1919.
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