Expression of STRBP mRNA in patients with cryptorchidism and Down's syndrome

M. Salemi, S. La Vignera, R. Castiglione, R. A. Condorelli, L. Cimino, P. Bosco, C. Romano, C. Romano, A. E. Calogero

Research output: Contribution to journalArticlepeer-review

Abstract

The most frequent defect of the male urogenital tract at birth is cryptorchidism. Cryptorchidism causes primitive testicular pathology responsible for infertility. Men with Down's syndrome (DS) have an increased risk of cryptorchidism. The spermatid perinuclear RNA-binding protein (STRBP) gene codifies a microtubule-associated RNA-binding protein and it is highly expressed in the testis as well as in the brain. At both levels, this gene seems to play a relevant role in the regular development of these organs. These observations prompted us to evaluate the expression of STRBP mRNA in 5 DS men with cryptorchidism and 5 normal healthy men (controls) by quantitative Real Time PCR in peripheral blood leukocytes. We found a decreased expression of the STRBP gene in men with DS and cryptorchidism compared with controls. This finding suggests that the impaired expression of this gene in DS may play a pathogenetic role in the altered brain and testicular development in subjects with DS and cryptorchidism.

Original languageEnglish
Pages (from-to)5-7
Number of pages3
JournalJournal of Endocrinological Investigation
Volume35
Issue number1
Publication statusPublished - Jan 2012

Keywords

  • Cryptorchidism
  • Down's syndrome
  • Expression
  • qRT-PCR
  • Reproductive genetics
  • STRSP gene

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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