Expression of synapsin I gene in primary cultures of differentiating rat cortical neurons

Italia Di Liegro, Giovanni Savettieri, Massimo Coppolino, Maria Scaturro, Maria Monte, Tommaso Nastasi, Giuseppe Salemi, Daniele Castiglia, Alessandro Cestelli

Research output: Contribution to journalArticle

Abstract

Synapsin I is a neuron-specific protein which is present in two isoforms, Ia and Ib. In the last few years this protein has been demonstrated to play a central role in the regulation of neurotransmitter release and synaptic plasticity. In this paper the developmental expression of this protein has been investigated in primary neuronal cultures from fetal rat brain cortices. The presence of thyroid hormone in the culture medium stimulates an early expression of the protein without exerting any effect at the level of mRNA transcription and accumulation. These observations implicate a T3-dependent regulation of this neuron-specific gene at the level of mRNA translation.

Original languageEnglish
Pages (from-to)239-243
Number of pages5
JournalNeurochemical Research
Volume20
Issue number2
DOIs
Publication statusPublished - Feb 1995

Keywords

  • Neuronal differentiation
  • synapsin I
  • thyroid hormones

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

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  • Cite this

    Di Liegro, I., Savettieri, G., Coppolino, M., Scaturro, M., Monte, M., Nastasi, T., Salemi, G., Castiglia, D., & Cestelli, A. (1995). Expression of synapsin I gene in primary cultures of differentiating rat cortical neurons. Neurochemical Research, 20(2), 239-243. https://doi.org/10.1007/BF00970550