Expression of the α6β4 integrin in lesional skin differentiates bullous pemphigoid (BP) from epidermolysis bullosa acquisita (EBA)

Hélène Michalaki, Marie Jeanne Staquet, Amilcare Cerri, Emilio Berti, Pascale Roche, Paulo Machado, Jean François Nicolas

Research output: Contribution to journalArticlepeer-review

Abstract

The integrin α6β4 complex is a protein of the membrane of basal keratinocytes, localized at the surface of cells in contact with the basement membrane zone in normal skin. The expression of α6β4 was investigated in several autoimmune blistering skin diseases including bullous pemphigoid (BP), epidermolysis bullosa acquisita (EBA), bullous systemic lupus erythematosus (BSLE), and pemphigus vulgaris (PV) by an indirect immunofluorescence technique. In lesional bullous skin of BP, α6β4 expression was either absent, or in some cases represented an unusual irregular patchy staining. In contrast, in lesional bullous skin from EBA, BSLE, and PV, α6β4 expression was comparable to that observed in normal skin, i.e., a linear staining of the BMZ. Thus, analysis of the α6β4 integrin reactivity on lesional skin, in conjunction with the typical localization of collagen IV, allows a rapid and accurate distinction between BP and EBA.

Original languageEnglish
Pages (from-to)204-208
Number of pages5
JournalJournal of Investigative Dermatology
Volume98
Issue number2
Publication statusPublished - Feb 1992

ASJC Scopus subject areas

  • Dermatology

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