Expression of the γ-globin gene is sustained by the cAMP-dependent pathway in β-thalassaemia

Lakiea Bailey, Yuichi Kuroyanagi, Carla F. Franco-Penteado, Nicola Conran, Fernando F. Costa, Sabrina Ausenda, Maria D. Cappellini, Tohru Ikuta

Research output: Contribution to journalArticle

Abstract

The present study found that the cyclic adenosine monophosphate (cAMP)-dependent pathway efficiently induced γ-globin expression in adult erythroblasts, and this pathway plays a role in γ-globin gene (HBG) expression in β-thalassaemia. Expression of HBG mRNA increased to about 46% of non-HBA mRNA in adult erythroblasts treated with forskolin, while a cyclic guanosine monophosphate (cGMP) analogue induced HBG mRNA to levels

Original languageEnglish
Pages (from-to)382-395
Number of pages14
JournalBritish Journal of Haematology
Volume138
Issue number3
DOIs
Publication statusPublished - Aug 2007

Keywords

  • β-thalassaemia
  • γ-globin
  • Cyclic adenosine monophosphate
  • Intracellular pathways
  • Signal transduction

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Bailey, L., Kuroyanagi, Y., Franco-Penteado, C. F., Conran, N., Costa, F. F., Ausenda, S., Cappellini, M. D., & Ikuta, T. (2007). Expression of the γ-globin gene is sustained by the cAMP-dependent pathway in β-thalassaemia. British Journal of Haematology, 138(3), 382-395. https://doi.org/10.1111/j.1365-2141.2007.06673.x