Expression of the 67 kD laminin receptor in human ovarian carcinomas as defined by a monoclonal antibody, MLuCS

F. A. Van Den Brûle, V. Castronovo, S. Ménard, R. Giavazzi, M. Marzola, D. Belotti, G. Taraboletti

Research output: Contribution to journalArticle

Abstract

Previous immunohistochemical data from our laboratory have demonstrated that expression of the 67 kD laminin receptor (67LR), a cancer-associated, high-affinity laminin-binding protein, is upregulated in ovarian carcinoma cells compared with normal serosal cells, and that this increased expression in cancer cells could be related to patient outcome. The aim of this study was to validate MLuCS, a monoclonal antibody that recognises the 67LR, as a tool to perform future immunohistochemical studies on larger populations of ovarian carcinoma patients. Expression of the 67LR was determined in 51 primary human ovarian carcinoma samples using immunohistochemistry and MLuCS. The 67LR was detected in ovarian carcinoma cell clusters of variable extent. Analysis of the data determined that 67LR expression was significantly increased in the samples from patients with disease progression, compared with those with no evidence of disease after completion of primary therapy, and in pooled grade 2 and 3 tumours compared to borderline and grade 1 tumours (P

Original languageEnglish
Pages (from-to)1585-1590
Number of pages6
JournalEuropean Journal of Cancer
Volume32
Issue number9
Publication statusPublished - 1996

Keywords

  • Immunohistochemistry
  • Laminin receptor
  • Ovarian cancer

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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