Expression of the Hoxa-13 gene correlates to Hepatitis B and C virus associated HCC

Ting Huang, Victor Chesnokov, Kazunari K. Yokoyama, Brian I. Carr, Keiichi Itakura

Research output: Contribution to journalArticle

Abstract

To study the Hoxa-13 gene in the liver, we examined its expression by RT-PCR in various liver cell lines, rat livers under different conditions, and human primary hepatocellular carcinomas (HCCs). The gene was found to be expressed in cell lines originating from liver stem-like cells, but not in cell lines originating from hepatocytes and bile duct epithelia. Expression was induced in rat livers after treatment with D-galactosamine, which is known to induce oval cell proliferation, but not after a two-thirds partial hepatectomy (2/3 PH) where induction of oval cell proliferation is thought not to occur. Expression of the gene correlated with human HCC samples associated with Hepatitis B or C virus infection in this small series. These results suggest that the Hoxa-13 gene may provide a potentially useful tool for elucidation of mechanisms involved in lineage-specific differentiation and carcinogenesis of liver stem cells.

Original languageEnglish
Pages (from-to)1041-1044
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume281
Issue number4
DOIs
Publication statusPublished - 2001

Keywords

  • Hepatitis virus
  • Hepatocellular carcinoma
  • Hepatoctye
  • Hox gene
  • Liver
  • Oval cell
  • Partial hepatectomy
  • Stem cell

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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