Expression of the intestinal T-lymphocyte associated molecule HML-1: Analysis of 75 non-Hodgkin's lymphomas and description of the first HML-1 positive T-lymphoblastic tumour

B. Falini, L. Flenghi, M. Fagioli, P. G. Pelicci, H. Stein, B. Bigerna, S. Pileri, M. F. Martelli

Research output: Contribution to journalArticlepeer-review

Abstract

The expression of the gut intra-epithelial T-cell associated molecule HML-1, a trimeric protein of 150, 125, 105 kD, was studied in 75 T-cell lymphomas of different subtypes: 20 T-lymphoblastic lymphomas/leukaemias; 50 nodal peripheral T-cell lymphomas; and five intestinal T-cell lymphomas. Our results confirm: (i) the usefulness of the HML-1 monoclonal antibody as an immunohistochemical marker for intestinal T-cell lymphomas; and (ii) the lack of reactivity of HML-1 with nodal peripheral T-cell lymphomas. Moreover, expression of the HML-1 molecule was found for the first time in a case of T-lymphoblastic lymphoma/leukaemia. The patient presented with a mediastinal mass which consisted of HML-1 + neoplastic cells displaying a phenotypic profile consistent with early thymocytes. Genes coding for the α, β, γ and δ chains of the T-cell receptor were in a germline configuration. The neoplastic cells could have been derived from the small subset of HML-1 + thymocytes detectable in the cortex of normal human thymus.

Original languageEnglish
Pages (from-to)421-426
Number of pages6
JournalHistopathology
Volume18
Issue number5
Publication statusPublished - 1991

Keywords

  • Intestinal mucosa
  • Monoclonal antibody HML-1
  • T-cell receptor
  • T-lymphoblastic lymphoma
  • T-lymphocytes

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

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