Expression of the pp63 gene encoding the insulin receptor tyrosine kinase inhibitor in proliferating liver and in liver tumors

Bruno M. Colombo, Laurence Falquerho, Giacomo Manenti, Tommaso A. Dragani, Alphonse Le Cam

Research output: Contribution to journalArticlepeer-review

Abstract

After partial hepatectomy in rats, a ≈4-fold decrease in pp63 mRNA level was detected at 24h, but not at earlier time points. In mice, during liver cell proliferation induced by 1,4-bis[2-(3,5-dichloropyridyloxy) ]benzene and phenobarbital, pp63 transcript levels had a decrease of 40-50%. However, pp63 mRNA was 5-6 fold higher in murine hepatocellular tumors than in normal adult mouse liver.

Original languageEnglish
Pages (from-to)967-971
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume180
Issue number2
DOIs
Publication statusPublished - Oct 31 1991

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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