Abstract
Background Vascular endothelial growth factor-C (VEGF-C), a lymphatic vessel growth factor, has been involved in the formation of lymph nodal metastases in different tumor types. Early evidences indicate that VEGF-C expression in human primary melanoma could be predictive of lymph nodal metastases, whereas the role of lymphangiogenesis is still controversial. Methods By immunohistochemical analysis, we investigated VEGF-C or CC chemokine receptor 7 expression, together with the lymphatic and blood vessel network, in 36 patients with primary skin melanomas and metastases at the sentinel lymph node biopsy (SLN-positive), and 26 melanoma patients with negative SLN biopsy (SLN-negative). Results We found that VEGF-C expression in primary melanoma specimens was significantly associated with SLN-positive (pâ
| Original language | English |
|---|---|
| Pages (from-to) | 826-834 |
| Number of pages | 9 |
| Journal | Journal of Cutaneous Pathology |
| Volume | 39 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2012 |
Fingerprint
Keywords
- immunohistochemistry
- lymphangiogenesis
- melanoma
- tumor marker
- VEGF-C
ASJC Scopus subject areas
- Dermatology
- Pathology and Forensic Medicine
- Histology
Cite this
Expression of vascular endothelial growth factor-C in primary cutaneous melanoma predicts sentinel lymph node positivity. / Cianfarani, Francesca; Mastroeni, Simona; Odorisio, Teresa; Passarelli, Francesca; Cattani, Caterina; Mannooranparampil, Thomas J.; Fortes, Cristina; Failla, Cristina M.
In: Journal of Cutaneous Pathology, Vol. 39, No. 9, 09.2012, p. 826-834.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of vascular endothelial growth factor-C in primary cutaneous melanoma predicts sentinel lymph node positivity
AU - Cianfarani, Francesca
AU - Mastroeni, Simona
AU - Odorisio, Teresa
AU - Passarelli, Francesca
AU - Cattani, Caterina
AU - Mannooranparampil, Thomas J.
AU - Fortes, Cristina
AU - Failla, Cristina M.
PY - 2012/9
Y1 - 2012/9
N2 - Background Vascular endothelial growth factor-C (VEGF-C), a lymphatic vessel growth factor, has been involved in the formation of lymph nodal metastases in different tumor types. Early evidences indicate that VEGF-C expression in human primary melanoma could be predictive of lymph nodal metastases, whereas the role of lymphangiogenesis is still controversial. Methods By immunohistochemical analysis, we investigated VEGF-C or CC chemokine receptor 7 expression, together with the lymphatic and blood vessel network, in 36 patients with primary skin melanomas and metastases at the sentinel lymph node biopsy (SLN-positive), and 26 melanoma patients with negative SLN biopsy (SLN-negative). Results We found that VEGF-C expression in primary melanoma specimens was significantly associated with SLN-positive (pâ
AB - Background Vascular endothelial growth factor-C (VEGF-C), a lymphatic vessel growth factor, has been involved in the formation of lymph nodal metastases in different tumor types. Early evidences indicate that VEGF-C expression in human primary melanoma could be predictive of lymph nodal metastases, whereas the role of lymphangiogenesis is still controversial. Methods By immunohistochemical analysis, we investigated VEGF-C or CC chemokine receptor 7 expression, together with the lymphatic and blood vessel network, in 36 patients with primary skin melanomas and metastases at the sentinel lymph node biopsy (SLN-positive), and 26 melanoma patients with negative SLN biopsy (SLN-negative). Results We found that VEGF-C expression in primary melanoma specimens was significantly associated with SLN-positive (pâ
KW - immunohistochemistry
KW - lymphangiogenesis
KW - melanoma
KW - tumor marker
KW - VEGF-C
UR - http://www.scopus.com/inward/record.url?scp=84865359623&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865359623&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0560.2012.01955.x
DO - 10.1111/j.1600-0560.2012.01955.x
M3 - Article
C2 - 22804631
AN - SCOPUS:84865359623
VL - 39
SP - 826
EP - 834
JO - Journal of Cutaneous Pathology
JF - Journal of Cutaneous Pathology
SN - 0303-6987
IS - 9
ER -