Expression of vascular endothelial growth factor-C in primary cutaneous melanoma predicts sentinel lymph node positivity

Francesca Cianfarani, Simona Mastroeni, Teresa Odorisio, Francesca Passarelli, Caterina Cattani, Thomas J. Mannooranparampil, Cristina Fortes, Cristina M. Failla

Research output: Contribution to journalArticlepeer-review

Abstract

Background Vascular endothelial growth factor-C (VEGF-C), a lymphatic vessel growth factor, has been involved in the formation of lymph nodal metastases in different tumor types. Early evidences indicate that VEGF-C expression in human primary melanoma could be predictive of lymph nodal metastases, whereas the role of lymphangiogenesis is still controversial. Methods By immunohistochemical analysis, we investigated VEGF-C or CC chemokine receptor 7 expression, together with the lymphatic and blood vessel network, in 36 patients with primary skin melanomas and metastases at the sentinel lymph node biopsy (SLN-positive), and 26 melanoma patients with negative SLN biopsy (SLN-negative). Results We found that VEGF-C expression in primary melanoma specimens was significantly associated with SLN-positive (pâ

Original languageEnglish
Pages (from-to)826-834
Number of pages9
JournalJournal of Cutaneous Pathology
Volume39
Issue number9
DOIs
Publication statusPublished - Sep 2012

Keywords

  • immunohistochemistry
  • lymphangiogenesis
  • melanoma
  • tumor marker
  • VEGF-C

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine
  • Histology

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