Expression of vascular endothelial growth factor-C in primary cutaneous melanoma predicts sentinel lymph node positivity

Francesca Cianfarani; Simona Mastroeni; Teresa Odorisio; Francesca Passarelli; Caterina Cattani; Thomas J. Mannooranparampil; Cristina Fortes; Cristina M. Failla

doi:10.1111/j.1600-0560.2012.01955.x

Expression of vascular endothelial growth factor-C in primary cutaneous melanoma predicts sentinel lymph node positivity

Francesca Cianfarani, Simona Mastroeni, Teresa Odorisio, Francesca Passarelli, Caterina Cattani, Thomas J. Mannooranparampil, Cristina Fortes, Cristina M. Failla

Istituto Dermopatico dell'Immacolata , IDI

Research output: Contribution to journal › Article › peer-review

Abstract

Background Vascular endothelial growth factor-C (VEGF-C), a lymphatic vessel growth factor, has been involved in the formation of lymph nodal metastases in different tumor types. Early evidences indicate that VEGF-C expression in human primary melanoma could be predictive of lymph nodal metastases, whereas the role of lymphangiogenesis is still controversial. Methods By immunohistochemical analysis, we investigated VEGF-C or CC chemokine receptor 7 expression, together with the lymphatic and blood vessel network, in 36 patients with primary skin melanomas and metastases at the sentinel lymph node biopsy (SLN-positive), and 26 melanoma patients with negative SLN biopsy (SLN-negative). Results We found that VEGF-C expression in primary melanoma specimens was significantly associated with SLN-positive (pâ

Original language	English
Pages (from-to)	826-834
Number of pages	9
Journal	Journal of Cutaneous Pathology
Volume	39
Issue number	9
DOIs	https://doi.org/10.1111/j.1600-0560.2012.01955.x
Publication status	Published - Sep 2012

Keywords

immunohistochemistry
lymphangiogenesis
melanoma
tumor marker
VEGF-C

ASJC Scopus subject areas

Dermatology
Pathology and Forensic Medicine
Histology

Access to Document

10.1111/j.1600-0560.2012.01955.x

Fingerprint Dive into the research topics of 'Expression of vascular endothelial growth factor-C in primary cutaneous melanoma predicts sentinel lymph node positivity'. Together they form a unique fingerprint.

Cite this

Expression of vascular endothelial growth factor-C in primary cutaneous melanoma predicts sentinel lymph node positivity. / Cianfarani, Francesca; Mastroeni, Simona ; Odorisio, Teresa; Passarelli, Francesca; Cattani, Caterina; Mannooranparampil, Thomas J.; Fortes, Cristina ; Failla, Cristina M.

In: Journal of Cutaneous Pathology, Vol. 39, No. 9, 09.2012, p. 826-834.

Research output: Contribution to journal › Article › peer-review

Cianfarani, Francesca ; Mastroeni, Simona ; Odorisio, Teresa ; Passarelli, Francesca ; Cattani, Caterina ; Mannooranparampil, Thomas J. ; Fortes, Cristina ; Failla, Cristina M. / Expression of vascular endothelial growth factor-C in primary cutaneous melanoma predicts sentinel lymph node positivity. In: Journal of Cutaneous Pathology. 2012 ; Vol. 39, No. 9. pp. 826-834.

@article{38b49e3bb9c949b79332a9518319d049,

title = "Expression of vascular endothelial growth factor-C in primary cutaneous melanoma predicts sentinel lymph node positivity",

abstract = "Background Vascular endothelial growth factor-C (VEGF-C), a lymphatic vessel growth factor, has been involved in the formation of lymph nodal metastases in different tumor types. Early evidences indicate that VEGF-C expression in human primary melanoma could be predictive of lymph nodal metastases, whereas the role of lymphangiogenesis is still controversial. Methods By immunohistochemical analysis, we investigated VEGF-C or CC chemokine receptor 7 expression, together with the lymphatic and blood vessel network, in 36 patients with primary skin melanomas and metastases at the sentinel lymph node biopsy (SLN-positive), and 26 melanoma patients with negative SLN biopsy (SLN-negative). Results We found that VEGF-C expression in primary melanoma specimens was significantly associated with SLN-positive (p{\^a}",

keywords = "immunohistochemistry, lymphangiogenesis, melanoma, tumor marker, VEGF-C",

author = "Francesca Cianfarani and Simona Mastroeni and Teresa Odorisio and Francesca Passarelli and Caterina Cattani and Mannooranparampil, {Thomas J.} and Cristina Fortes and Failla, {Cristina M.}",

year = "2012",

month = sep,

doi = "10.1111/j.1600-0560.2012.01955.x",

language = "English",

volume = "39",

pages = "826--834",

journal = "Journal of Cutaneous Pathology",

issn = "0303-6987",

publisher = "Wiley-Blackwell",

number = "9",

}

TY - JOUR

T1 - Expression of vascular endothelial growth factor-C in primary cutaneous melanoma predicts sentinel lymph node positivity

AU - Cianfarani, Francesca

AU - Mastroeni, Simona

AU - Odorisio, Teresa

AU - Passarelli, Francesca

AU - Cattani, Caterina

AU - Mannooranparampil, Thomas J.

AU - Fortes, Cristina

AU - Failla, Cristina M.

PY - 2012/9

Y1 - 2012/9

N2 - Background Vascular endothelial growth factor-C (VEGF-C), a lymphatic vessel growth factor, has been involved in the formation of lymph nodal metastases in different tumor types. Early evidences indicate that VEGF-C expression in human primary melanoma could be predictive of lymph nodal metastases, whereas the role of lymphangiogenesis is still controversial. Methods By immunohistochemical analysis, we investigated VEGF-C or CC chemokine receptor 7 expression, together with the lymphatic and blood vessel network, in 36 patients with primary skin melanomas and metastases at the sentinel lymph node biopsy (SLN-positive), and 26 melanoma patients with negative SLN biopsy (SLN-negative). Results We found that VEGF-C expression in primary melanoma specimens was significantly associated with SLN-positive (pâ

AB - Background Vascular endothelial growth factor-C (VEGF-C), a lymphatic vessel growth factor, has been involved in the formation of lymph nodal metastases in different tumor types. Early evidences indicate that VEGF-C expression in human primary melanoma could be predictive of lymph nodal metastases, whereas the role of lymphangiogenesis is still controversial. Methods By immunohistochemical analysis, we investigated VEGF-C or CC chemokine receptor 7 expression, together with the lymphatic and blood vessel network, in 36 patients with primary skin melanomas and metastases at the sentinel lymph node biopsy (SLN-positive), and 26 melanoma patients with negative SLN biopsy (SLN-negative). Results We found that VEGF-C expression in primary melanoma specimens was significantly associated with SLN-positive (pâ

KW - immunohistochemistry

KW - lymphangiogenesis

KW - melanoma

KW - tumor marker

KW - VEGF-C

UR - http://www.scopus.com/inward/record.url?scp=84865359623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865359623&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0560.2012.01955.x

DO - 10.1111/j.1600-0560.2012.01955.x

M3 - Article

C2 - 22804631

AN - SCOPUS:84865359623

VL - 39

SP - 826

EP - 834

JO - Journal of Cutaneous Pathology

JF - Journal of Cutaneous Pathology

SN - 0303-6987

IS - 9

ER -