Expression of vascular remodelling markers in relation to bradykinin receptors in asthma and COPD

Fabio L M Ricciardolo, Federica Sabatini, Valentina Sorbello, Sabrina Benedetto, Ilaria Defilippi, Loredana Petecchia, Cesare Usai, Isabella Gnemmi, Bruno Balbi, Virginia De Rose, Nick H T Ten Hacken, Dirkje S. Postma, Wim Timens, Antonino Di Stefano

Research output: Contribution to journalArticlepeer-review

Abstract

Background Vascular remodelling plays a central role in asthma and chronic obstructive pulmonary disease (COPD). Bradykinin (BK) is a vasoactive proinflammatory peptide mediating acute responses in asthma. We investigated the role of angiogenic factors in relation to BK receptors in asthma and COPD. Methods Bronchial biopsies from 33 patients with COPD, 24 old (≥50 years) patients with (≥50 years) asthma, 18 old control smokers, 11 old control nonsmokers, 15 young (≤40yrs) patients with (≤40 years) asthma and 10 young control non-smokers were immunostained for CD31, vascular endothelial growth factor-A (VEGF-A), angiogenin and BK receptors (B2R and B1R). Fibroblast and endothelial co-localisation of relevant molecules were performed by immunofluorescence. BK-induced VEGF-A and angiogenin release was studied (ELISA) in bronchial fibroblasts from subjects with asthma and COPD. Results In bronchial lamina propria of old patients with asthma, CD31 and VEGF-A+ cell numbers were higher than old control non-smokers ( p

Original languageEnglish
Pages (from-to)803-811
Number of pages9
JournalThorax
Volume68
Issue number9
DOIs
Publication statusPublished - Sep 2013

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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