Expression Profile of Long Non-Coding RNAs in Serum of Patients with Multiple Sclerosis

Massimo Santoro, Viviana Nociti, Matteo Lucchini, Chiara De Fino, Francesco Antonio Losavio, Massimiliano Mirabella

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple sclerosis (MS) is a chronic progressive inflammatory disease of the central nervous system (CNS) that leads to severe neurological disability. There is an interest in potential biomarkers that could provide information predicting disease activity and progression. Long non-coding RNAs (lncRNAs) have been reported to be involved in the pathogenesis of various human disorders, such as oncologic, cardiovascular, and neurodegenerative diseases. No studies have so far explored a potential link between lncRNAs and MS pathology. We screened 84 lncRNAs, involved in autoimmunity and human inflammatory response, in the serum of relapsing-remitting MS (RR-MS) patients (n = 12), age-matched controls (n = 12), and in patients with idiopathic inflammatory myopathy (IIM) (n = 12). We used the following criteria for lncRNAs analysis: fold change >2 and p 

Original languageEnglish
Pages (from-to)18-23
Number of pages6
JournalJournal of Molecular Neuroscience
Volume59
Issue number1
DOIs
Publication statusPublished - May 1 2016

Keywords

  • Autoimmunity
  • Long non-coding RNA
  • Multiple sclerosis
  • Neurodegeneration

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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