Expression profiles in malignant fibrous histiocytomas: Clues for differentiating 'spindle cell' and 'pleomorphic' subtypes

Martina Scapolan, Tiziana Perin, Bruna Wassermann, Vincenzo Canzonieri, Alfonso Colombatti, Fabrizio Italia, Paola Spessotto

Research output: Contribution to journalArticle

Abstract

We analysed 21 samples of malignant fibrous histiocytoma (MFH) distinguished into the two principal morphological categories ('spindle cell' and the 'pleomorphic' subtypes). The aim of our study was to verify if a distinction between the two subclasses of MFH in terms of expression/activation of protein profiles could support and extend the morphological criteria. For this purpose, we carried out an immunohistochemical and immunoblotting analysis of proteins that could be relevant in sarcoma biology and potential diagnostic and therapeutical targets such as matrix metalloproteinases (MMPs) and molecules related to adhesive and proliferative properties. Our analysis revealed that MMP-1, MMP-9 expression and p27(kip1) cytoplasmic localisation can be considered valid parameters in the classification and potential explanation of the aggressive behaviour of this non-homogeneous group of MFH.

Original languageEnglish
Pages (from-to)298-309
Number of pages12
JournalEuropean Journal of Cancer
Volume44
Issue number2
DOIs
Publication statusPublished - Jan 2008

Keywords

  • Malignant fibrous histiocytoma
  • MMP-1
  • MMP-9
  • p27(kip1)

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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