Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements

T. Rozovskaia, O. Ravid-Amir, S. Tillib, G. Getz, E. Feinstein, H. Agrawal, A. Nagler, E. F. Rappaport, I. Issaeva, Y. Matsuo, U. R. Kees, T. Lapidot, F. Lo Coco, R. Foa, A. Mazo, T. Nakamura, C. M. Croce, G. Cimino, E. Domany, E. Canaani

Research output: Contribution to journalArticle

Abstract

The ALL-1 gene is directly involved in 5-10% of acute lymphoblastic leukemias (ALLs) and acute myeloid leukemias (AMLs) by fusion to other genes or through internal rearrangements. DNA microarrays were used to determine expression profiles of ALLs and AMLs with ALL-1 rearrangements. These profiles distinguish those tumors from other ALLs and AMLs. The expression patterns of ALL-1-associated tumors, in particular ALLs, involve oncogenes, tumor suppressors, antiapoptotic genes, drug-resistance genes, etc., and correlate with the aggressive nature of the tumors. The genes whose expression differentiates between ALLs with and without ALL-1 rearrangement were further divided into several groups, enabling separation of ALL-1-associated ALLs into two subclasses. One of the groups included 43 genes that exhibited expression profiles closely linked to ALLs with ALL-1 rearrangements. Further, there were evident differences between the expression profiles of AMLs in which ALL-1 had undergone fusion to other genes and AMLs with partial duplication of ALL-1. The extensive analysis described here pinpointed genes that might have a direct role in pathogenesis.

Original languageEnglish
Pages (from-to)7853-7858
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume100
Issue number13
DOIs
Publication statusPublished - Jun 24 2003

ASJC Scopus subject areas

  • Genetics
  • General

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    Rozovskaia, T., Ravid-Amir, O., Tillib, S., Getz, G., Feinstein, E., Agrawal, H., Nagler, A., Rappaport, E. F., Issaeva, I., Matsuo, Y., Kees, U. R., Lapidot, T., Lo Coco, F., Foa, R., Mazo, A., Nakamura, T., Croce, C. M., Cimino, G., Domany, E., & Canaani, E. (2003). Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements. Proceedings of the National Academy of Sciences of the United States of America, 100(13), 7853-7858. https://doi.org/10.1073/pnas.1132115100