Expression profiles of exosomal miRNAs isolated from plasma of patients with desmoplastic small round cell tumor

Marta Colletti, Alessandro Paolini, Angela Galardi, Virginia Di Paolo, Luisa Pascucci, Ida Russo, Biagio De Angelis, Hector Peinado, Rita De Vito, Giuseppe M Milano, Franco Locatelli, Andrea Masotti, Angela Di Giannatale

Research output: Contribution to journalArticlepeer-review

Abstract

AIM: Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive mesenchymal tumor, lacking biomarkers for diagnosis, treatment stratification and prognosis. We investigated the exosomal miRNA profile in plasma samples collected from DSRCT patients, evaluating their potential as circulating biomarkers for this tumor.

PATIENTS & METHODS: We isolated exosomes from plasma of three DSRCT adolescents and four age-matched healthy controls; expression of circulating miRNAs was quantified by qPCR.

RESULTS: We identified 55 miRNAs significantly modulated compared with healthy controls. Among these miRNAs, 14 were highly dysregulated in at least one patient and 5 were expressed in all patients.

CONCLUSION: To our knowledge, this is the first report describing exosomal miRNAs as promising biomarkers to characterize disease status in DSRCT patients.

Original languageEnglish
JournalEpigenomics
DOIs
Publication statusE-pub ahead of print - Dec 20 2018

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