EXT-mutation analysis in Italian sporadic and hereditary osteochondromas

Maddalena Gigante, Maria G. Matera, Davide Seripa, Apollonia M. Izzo, Riccardo Venanzi, Aldo Giannotti, Maria C. Digilio, Carolina Gravina, Marzia Lazzari, Giovanni Monteleone, Maurizio Monteleone, Bruno Dallapiccola, Vito M. Fazio

Research output: Contribution to journalArticlepeer-review

Abstract

Osteochondromas represent the largest group of benign tumors of bone. Multiple osteochondromatosis or hereditary multiple exostoses (EXT) is an autosomal dominant inherited disorder characterized by the presence of multiple benign cartilage-capped exostoses. EXT is genetically heterogeneous with at least 3 chromosomal loci: EXT1 (8q24.1), EXT2 (11p11-p13), and EXT3 (19p). In

Original languageEnglish
Pages (from-to)378-383
Number of pages6
JournalInternational Journal of Cancer
Volume95
Issue number6
DOIs
Publication statusPublished - Nov 20 2001

Keywords

  • BcDNA: GH02288
  • Chondroma
  • Chondrosarcoma
  • DNA-SSCP
  • Drosophila
  • Exostoses
  • Exostosin
  • EXT
  • EXT1
  • EXT2
  • Germline mutations
  • Hereditary tumors
  • Mouse
  • PCR
  • Tumor suppressor genes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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