Abstract
Osteochondromas represent the largest group of benign tumors of bone. Multiple osteochondromatosis or hereditary multiple exostoses (EXT) is an autosomal dominant inherited disorder characterized by the presence of multiple benign cartilage-capped exostoses. EXT is genetically heterogeneous with at least 3 chromosomal loci: EXT1 (8q24.1), EXT2 (11p11-p13), and EXT3 (19p). In
Original language | English |
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Pages (from-to) | 378-383 |
Number of pages | 6 |
Journal | International Journal of Cancer |
Volume | 95 |
Issue number | 6 |
DOIs | |
Publication status | Published - Nov 20 2001 |
Keywords
- BcDNA: GH02288
- Chondroma
- Chondrosarcoma
- DNA-SSCP
- Drosophila
- Exostoses
- Exostosin
- EXT
- EXT1
- EXT2
- Germline mutations
- Hereditary tumors
- Mouse
- PCR
- Tumor suppressor genes
ASJC Scopus subject areas
- Cancer Research
- Oncology