Extended follow-up following "full-metal jacket" percutaneous coronary interventions with drug-eluting stents

Sandeep Basavarajaiah, Toru Naganuma, Azeem Latib, Tasuku Hasegawa, Andrew Sharp, Ahmed Rezq, Alessandro Sticchi, Filipo Figini, Antonio Amato, Antonio Colombo

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objectives: To report very long-term follow-up of "Full-Metal Jacket" (FMJ) percutaneous coronary interventions (PCI) in long-diffuse coronary lesions with drug-eluting stents (DES).

Background: PCI for long-diffuse lesions may result in FMJ, which is not preferred by some operators due to long-term risk of restenosis and stent thrombosis. The data on long-term follow-up of patients with FMJ are limited and would be useful in understanding the safety and feasibility of such a strategy. Methods: Between April 2002 and March 2007, 274 patients (297 lesions in native coronary arteries) underwent PCI utilizing DES. FMJ was described as lesions requiring≥60 mm of continuous stent. The measured endpoints were cardiac death, target-vessel myocardial infarction (MI), target lesion revascularization (TLR), target-vessel revascularization (TVR), and major adverse cardiac events (MACE) defined as composite of cardiac death, target-vessel MI, and TVR.

Results: The mean age of patients was 62.1±11 years. The mean length of total stents used was 75.1±16.4 mm (60-150). During the median follow-up of 74.7 months (interquartile range: 58-96), the rates of cardiac death, MI, TLR, and TVR were: 5.8% (n=16), 6.2% (n=17), 27.3% (n=81), and 30% (n=89), respectively. The MACE rate was 34%. Definite and probable stent thrombosis occurred in 10 patients (3.6%).

Conclusion: The long-term follow-up of patients with FMJ is acceptable especially in regards to hard endpoints (death and MI) given the complexity of lesions treated. The high MACE rate was driven mainly by TVR. The availability of newer-generation DES and bioabsorbable scaffolds may improve these results..

Original languageEnglish
Pages (from-to)1042-1050
Number of pages9
JournalCatheterization and Cardiovascular Interventions
Volume84
Issue number7
DOIs
Publication statusPublished - Dec 1 2014

Fingerprint

Drug-Eluting Stents
Percutaneous Coronary Intervention
Metals
Stents
Myocardial Infarction
Thrombosis
Coronary Vessels
Safety

Keywords

  • Drug-eluting stents
  • Full-metal jacket
  • Long-diffuse lesions

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Extended follow-up following "full-metal jacket" percutaneous coronary interventions with drug-eluting stents. / Basavarajaiah, Sandeep; Naganuma, Toru; Latib, Azeem; Hasegawa, Tasuku; Sharp, Andrew; Rezq, Ahmed; Sticchi, Alessandro; Figini, Filipo; Amato, Antonio; Colombo, Antonio.

In: Catheterization and Cardiovascular Interventions, Vol. 84, No. 7, 01.12.2014, p. 1042-1050.

Research output: Contribution to journalArticle

Basavarajaiah, S, Naganuma, T, Latib, A, Hasegawa, T, Sharp, A, Rezq, A, Sticchi, A, Figini, F, Amato, A & Colombo, A 2014, 'Extended follow-up following "full-metal jacket" percutaneous coronary interventions with drug-eluting stents', Catheterization and Cardiovascular Interventions, vol. 84, no. 7, pp. 1042-1050. https://doi.org/10.1002/ccd.25455
Basavarajaiah, Sandeep ; Naganuma, Toru ; Latib, Azeem ; Hasegawa, Tasuku ; Sharp, Andrew ; Rezq, Ahmed ; Sticchi, Alessandro ; Figini, Filipo ; Amato, Antonio ; Colombo, Antonio. / Extended follow-up following "full-metal jacket" percutaneous coronary interventions with drug-eluting stents. In: Catheterization and Cardiovascular Interventions. 2014 ; Vol. 84, No. 7. pp. 1042-1050.
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T1 - Extended follow-up following "full-metal jacket" percutaneous coronary interventions with drug-eluting stents

AU - Basavarajaiah, Sandeep

AU - Naganuma, Toru

AU - Latib, Azeem

AU - Hasegawa, Tasuku

AU - Sharp, Andrew

AU - Rezq, Ahmed

AU - Sticchi, Alessandro

AU - Figini, Filipo

AU - Amato, Antonio

AU - Colombo, Antonio

PY - 2014/12/1

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N2 - Objectives: To report very long-term follow-up of "Full-Metal Jacket" (FMJ) percutaneous coronary interventions (PCI) in long-diffuse coronary lesions with drug-eluting stents (DES).Background: PCI for long-diffuse lesions may result in FMJ, which is not preferred by some operators due to long-term risk of restenosis and stent thrombosis. The data on long-term follow-up of patients with FMJ are limited and would be useful in understanding the safety and feasibility of such a strategy. Methods: Between April 2002 and March 2007, 274 patients (297 lesions in native coronary arteries) underwent PCI utilizing DES. FMJ was described as lesions requiring≥60 mm of continuous stent. The measured endpoints were cardiac death, target-vessel myocardial infarction (MI), target lesion revascularization (TLR), target-vessel revascularization (TVR), and major adverse cardiac events (MACE) defined as composite of cardiac death, target-vessel MI, and TVR.Results: The mean age of patients was 62.1±11 years. The mean length of total stents used was 75.1±16.4 mm (60-150). During the median follow-up of 74.7 months (interquartile range: 58-96), the rates of cardiac death, MI, TLR, and TVR were: 5.8% (n=16), 6.2% (n=17), 27.3% (n=81), and 30% (n=89), respectively. The MACE rate was 34%. Definite and probable stent thrombosis occurred in 10 patients (3.6%).Conclusion: The long-term follow-up of patients with FMJ is acceptable especially in regards to hard endpoints (death and MI) given the complexity of lesions treated. The high MACE rate was driven mainly by TVR. The availability of newer-generation DES and bioabsorbable scaffolds may improve these results..

AB - Objectives: To report very long-term follow-up of "Full-Metal Jacket" (FMJ) percutaneous coronary interventions (PCI) in long-diffuse coronary lesions with drug-eluting stents (DES).Background: PCI for long-diffuse lesions may result in FMJ, which is not preferred by some operators due to long-term risk of restenosis and stent thrombosis. The data on long-term follow-up of patients with FMJ are limited and would be useful in understanding the safety and feasibility of such a strategy. Methods: Between April 2002 and March 2007, 274 patients (297 lesions in native coronary arteries) underwent PCI utilizing DES. FMJ was described as lesions requiring≥60 mm of continuous stent. The measured endpoints were cardiac death, target-vessel myocardial infarction (MI), target lesion revascularization (TLR), target-vessel revascularization (TVR), and major adverse cardiac events (MACE) defined as composite of cardiac death, target-vessel MI, and TVR.Results: The mean age of patients was 62.1±11 years. The mean length of total stents used was 75.1±16.4 mm (60-150). During the median follow-up of 74.7 months (interquartile range: 58-96), the rates of cardiac death, MI, TLR, and TVR were: 5.8% (n=16), 6.2% (n=17), 27.3% (n=81), and 30% (n=89), respectively. The MACE rate was 34%. Definite and probable stent thrombosis occurred in 10 patients (3.6%).Conclusion: The long-term follow-up of patients with FMJ is acceptable especially in regards to hard endpoints (death and MI) given the complexity of lesions treated. The high MACE rate was driven mainly by TVR. The availability of newer-generation DES and bioabsorbable scaffolds may improve these results..

KW - Drug-eluting stents

KW - Full-metal jacket

KW - Long-diffuse lesions

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