Extended lymphadenectomy (D2) in patients with early gastric cancer

Donato Nitti, A. Marchet, E. Mammano, A. Ambrosi, C. Belluco, R. Mencarelli, M. Maino, G. Marconato, F. Farinati, M. Lise

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Abstract

Aims: To investigate the survival benefit of extended lymphadenectomy (D2) in EGC patients in one European Institution. Methods: A review was made of our prospective gastric database from January 1980 to December 2001. Of 527 patients with primary gastric adenocarcinoma, 119 with EGC underwent potentially curative resection (R0) with D2 lymphadenectomy. Results: There were two post-operative deaths. Of the 117 evaluable cases, 96 were classified as N0 and 21 as N+, with metastases in the perigastric lymph nodes (level 1) in 13, and beyond this site (level 2) in eight. Five-year survival was 85.9 and 83.0% in N0 and N+ patients, respectively. During a median follow-up of 90 months, five of the eight patients with level 2 metastases died of recurrent disease and three were alive. The estimated survival benefit for 119 patients with EGC was 2.5% (3/119 cases). Conclusions: In patients with EGC, metastases to level 2 are rare. Our results indicate that D2 lymphadenectomy has a limited survival benefit and that in these cases a less extensive lymphadenectomy (D1) could be performed.

Original languageEnglish
Pages (from-to)875-881
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume31
Issue number8
DOIs
Publication statusPublished - Oct 2005

Fingerprint

Lymph Node Excision
Stomach Neoplasms
Survival
Neoplasm Metastasis
Stomach
Adenocarcinoma
Lymph Nodes
Databases

Keywords

  • Early gastric cancer
  • Lymphadenectomy
  • Prognosis
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Nitti, D., Marchet, A., Mammano, E., Ambrosi, A., Belluco, C., Mencarelli, R., ... Lise, M. (2005). Extended lymphadenectomy (D2) in patients with early gastric cancer. European Journal of Surgical Oncology, 31(8), 875-881. https://doi.org/10.1016/j.ejso.2005.05.013

Extended lymphadenectomy (D2) in patients with early gastric cancer. / Nitti, Donato; Marchet, A.; Mammano, E.; Ambrosi, A.; Belluco, C.; Mencarelli, R.; Maino, M.; Marconato, G.; Farinati, F.; Lise, M.

In: European Journal of Surgical Oncology, Vol. 31, No. 8, 10.2005, p. 875-881.

Research output: Contribution to journalArticle

Nitti, D, Marchet, A, Mammano, E, Ambrosi, A, Belluco, C, Mencarelli, R, Maino, M, Marconato, G, Farinati, F & Lise, M 2005, 'Extended lymphadenectomy (D2) in patients with early gastric cancer', European Journal of Surgical Oncology, vol. 31, no. 8, pp. 875-881. https://doi.org/10.1016/j.ejso.2005.05.013
Nitti, Donato ; Marchet, A. ; Mammano, E. ; Ambrosi, A. ; Belluco, C. ; Mencarelli, R. ; Maino, M. ; Marconato, G. ; Farinati, F. ; Lise, M. / Extended lymphadenectomy (D2) in patients with early gastric cancer. In: European Journal of Surgical Oncology. 2005 ; Vol. 31, No. 8. pp. 875-881.
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