Extensive conservation of sequences and chromatin structures in the bxd Polycomb Response Element among Drosophilid species

Gaetano I. Dellino, Christophe Tatout, Vincenzo Pirrotta

Research output: Contribution to journalArticle

Abstract

The Polycomb Response Element (PRE) is the nucleation site for the Polycomb silencing complexes. The sequences responsible for the recruitment of the components of the Polycomb complex are not well understood. A comparison of the bxd PRE sequences from several different Drosophila species shows that some changes have occurred during phylogeny but large blocks of sequence are conserved after a divergence of some 60 million years. We compare the PRE sequences, the sites of some known PRE binding proteins, the conservation of DNasel hypersensitive sites and relate them to the sequence of the Ultrabithorax promoter which these PREs regulate.

Original languageEnglish
Pages (from-to)133-141
Number of pages9
JournalInternational Journal of Developmental Biology
Volume46
Issue number1
Publication statusPublished - 2002

Keywords

  • Chromatin structure
  • Evolutionary conservation
  • Polycomb silencing

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Extensive conservation of sequences and chromatin structures in the bxd Polycomb Response Element among Drosophilid species'. Together they form a unique fingerprint.

  • Cite this