Extensive cortical damage in a case of Creutzfeldt-Jacob disease: Clinicoradiologic correlations

M. Bergui, Gianni Boris Bradac, G. Rossi, L. Orsi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

MRI demonstrated extensive cortical involvement in a patient with pathologically proven Creutzfeldt-Jacob disease. The whole brain was atrophic; some of the supratentorial cortex, putamen and caudate nucleus gave high signal on T2-weighted images; the changes were more extensive on diffusion-weighted images (DWI). Comparison of the history, and the sites of atrophy and signal change suggested that the latter predominates in regions with long-lasting damage and prevalent gliosis, while high signal on DWI indicate current neuronal loss. This case widens the range of MRI findings in patients with Creutzfeldt-Jacob disease, and suggests that some information about the progression of the disease can be extracted from single MRI study.

Original languageEnglish
Pages (from-to)304-307
Number of pages4
JournalNeuroradiology
Volume45
Issue number5
Publication statusPublished - May 1 2003

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Creutzfeldt-Jakob Syndrome
Gliosis
Caudate Nucleus
Putamen
Atrophy
Disease Progression
History
Brain

Keywords

  • Creutzfeldt-Jacob disease
  • Diffusion-weighted imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Radiological and Ultrasound Technology

Cite this

Bergui, M., Bradac, G. B., Rossi, G., & Orsi, L. (2003). Extensive cortical damage in a case of Creutzfeldt-Jacob disease: Clinicoradiologic correlations. Neuroradiology, 45(5), 304-307.

Extensive cortical damage in a case of Creutzfeldt-Jacob disease : Clinicoradiologic correlations. / Bergui, M.; Bradac, Gianni Boris; Rossi, G.; Orsi, L.

In: Neuroradiology, Vol. 45, No. 5, 01.05.2003, p. 304-307.

Research output: Contribution to journalArticle

Bergui, M, Bradac, GB, Rossi, G & Orsi, L 2003, 'Extensive cortical damage in a case of Creutzfeldt-Jacob disease: Clinicoradiologic correlations', Neuroradiology, vol. 45, no. 5, pp. 304-307.
Bergui, M. ; Bradac, Gianni Boris ; Rossi, G. ; Orsi, L. / Extensive cortical damage in a case of Creutzfeldt-Jacob disease : Clinicoradiologic correlations. In: Neuroradiology. 2003 ; Vol. 45, No. 5. pp. 304-307.
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