Extensive modulation of a set of microRNAs in primary glioblastoma

S. A. Ciafrè, S. Galardi, A. Mangiola, M. Ferracin, C. G. Liu, G. Sabatino, M. Negrini, G. Maira, C. M. Croce, M. G. Farace

Research output: Contribution to journalArticlepeer-review

Abstract

MicroRNAs (miRNAs) are short non-coding RNA molecules playing regulatory roles in animals and plants by repressing translation or cleaving RNA transcripts. The specific modulation of several microRNAs has been recently associated to some forms of human cancer, suggesting that these short molecules may represent a new class of genes involved in oncogenesis. In our study, we examined by microarray the global expression levels of 245 microRNAs in glioblastoma multiforme, the most frequent and malignant of primary brain tumors. The analysis of both glioblastoma tissues and glioblastoma cell lines allowed us to identify a group of microRNAs whose expression is significantly altered in this tumor. The most interesting results came from miR-221, strongly up-regulated in glioblastoma and from a set of brain-enriched miRNAs, miR-128, miR-181a, miR-181b, and miR-181c, which are down-regulated in glioblastoma.

Original languageEnglish
Pages (from-to)1351-1358
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume334
Issue number4
DOIs
Publication statusPublished - Sep 9 2005

Keywords

  • Brain
  • Cancer
  • Cell lines
  • Differentiation
  • Glioblastoma
  • Microarray
  • MicroRNA
  • Oncogenes
  • RNA
  • Tumor-marker

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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