Extensive precursor-product relationship between gangliosides formed from exogenous glucosylceramide in rat liver

Marco Trinchera, Carlo Vallenzasca, Riccardo Ghidoni, Guido Tettamanti

Research output: Contribution to journalArticlepeer-review

Abstract

Glucosylceramide, radiolabelled on the glucose residue, was administered to rats and the radioactive gangliosides formed at different time points were chemically characterized. They were identified as GM3, GM1, GD1a and GD1b, each one carrying only radioactive glucose. The time course of each individual ganglioside showed that the simpler gangliosides were formed earlier but were consumed earlier than the more complex ones, resulting in radioactivity patterns that were different at each time point. Only 30 h after injection did it resemble that of endogenous rat liver gangliosides. These results indicate that an extensive precursor-product relationship actually exists in the course of ganglioside biosynthesis.

Original languageEnglish
Pages (from-to)23-26
Number of pages4
JournalFEBS Letters
Volume260
Issue number1
DOIs
Publication statusPublished - Jan 15 1990

Keywords

  • Ganglioside
  • Glucosylceramide
  • Glycosylation
  • Golgi apparatus

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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