Extensive use of peripheral angioplasty, particularly infrapopliteal, in the treatment of ischaemic diabetic foot ulcers: Clinical results of a multicentric study of 221 consecutive diabetic subjects

E. Faglia, M. Mantero, M. Caminiti, C. Caravaggi, R. De Giglio, C. Pritelli, G. Clerici, P. Fratino, P. De Cata, L. Dalla Paola, G. Mariani, M. Poli, P. G. Settembrini, L. Sciangula, A. Morabito, L. Graziani

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives. To evaluate the feasibility, technical effectiveness and limb salvage potential of percutaneous transluminal angioplasty (PTA), particularly infrapopliteal, in diabetic subjects with ischaemic foot ulcer. Design. Intervention study with PTA in consecutive series. Setting. Six Diabetology Foot Centres and one Cardiovascular Catheterization Laboratory in Italy. Subjects. Two hundred and twenty-one consecutive diabetic subjects hospitalized for ischaemic foot ulcer. Interventions. Peripheral arterial occlusive disease (PAOD) was investigated by means of foot pulses assessment, ankle-brachial-index (ABI), transcutaneous oxygen tension (TcPO2) and duplex scanning. If non-invasive parameters suggested PAOD, angiography was performed and a PTA was carried out during the same session. Main outcome measures. PTA feasibility, improvement of ABI and TcPO2, limb salvage rate, clinical recurrence. Results. On angiography, two patients had stenoses which were 50%, even when longer than 10 cm and/or multiple/calcified. In 11 patients (5.8%) PTA was performed in the proximal axis exclusively, in 81 (42.4%) patients in the infrapopliteal axis exclusively and in 99 (51.8%) in both the femoropopliteal and infrapopliteal axis. Both ABI and TcPO2 improved significantly after PTA (P <0.0001). Clinical recurrence occurred in 14 subjects: 10 of whom underwent a second successful PTA. Of the 191 patients who underwent PTA, 10 (5.2%) underwent an above-the-ankle amputation. Conclusions. PTA, including infrapopliteal, is feasible in most diabetic subjects with ischaemic foot ulcer and is effective for foot revascularization. Clinical recurrence was infrequent and the procedure could successfully be repeated in most cases. In subjects treated successfully with PTA the above-the-ankle amputation rate was low. PTA should be considered as the revascularization treatment of first choice in all diabetic subjects with foot ulcer and PAOD.

Original languageEnglish
Pages (from-to)225-232
Number of pages8
JournalJournal of Internal Medicine
Volume252
Issue number3
DOIs
Publication statusPublished - 2002

Keywords

  • Diabetic foot ulcer
  • Infrapopliteal angioplasty
  • Major amputation
  • Minor amputation
  • Peripheral arterial occlusive disease

ASJC Scopus subject areas

  • Internal Medicine

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