Extensively drug-resistant ArmA-producing Acinetobacter baumannii in an Italian intensive care unit

Carla Caio, Gaetano Maugeri, Tiziana Zingali, Floriana Gona, Stefania Stefani, Maria Lina Mezzatesta

Research output: Contribution to journalArticlepeer-review

Abstract

We describe the spread of 12 carbapenem-resistant Acinetobacter baumannii isolates in hospitalized patients. All strains showed an extensively drug-resistant phenotype and high-level of aminoglycoside resistance, harboring the ArmA gene and blaoxa-23 downstream of ISAba1 (transposon Tn2008 arrangement) where both were located on the chromosome. These strains carry a class 1 integron containing the gene cassette aacA4-catB8-aadA1. Molecular analysis revealed that all isolates belonged to the same sequence type (ST) 2 clone. The spread of ArmA-producing A. baumannii strains limit the treatment options showing the dramatic situation which requires novel therapies to limit high mortality rates.

Original languageEnglish
Pages (from-to)159-161
Number of pages3
JournalThe new microbiologica
Volume41
Issue number2
Publication statusPublished - Apr 2018

Keywords

  • Acinetobacter Infections/microbiology
  • Acinetobacter baumannii/drug effects
  • Anti-Bacterial Agents/pharmacology
  • Bacterial Proteins/genetics
  • Carbapenems/pharmacology
  • Cross Infection/microbiology
  • Drug Resistance, Multiple, Bacterial/genetics
  • Humans
  • Intensive Care Units
  • Italy/epidemiology
  • Microbial Sensitivity Tests

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