TY - JOUR
T1 - Extent of lung involvement over severity of cardiac disease for the prediction of adverse outcome in COVID-19 patients with cardiovascular disease
AU - Andreini, Daniele
AU - Conte, Edoardo
AU - Mushtaq, Saima
AU - Gigante, Carlo
AU - Mancini, Maria Elisabetta
AU - Annoni, Andrea
AU - Stefanini, Giulio
AU - Agalbato, Cecilia
AU - Cosentino, Nicola
AU - Pontone, Gianluca
AU - Assanelli, Emilio
AU - Pepi, Mauro
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2021/1/15
Y1 - 2021/1/15
N2 - Background: Aim of the present study was to assess if the presence of high cardiovascular risk, left ventricle systolic dysfunction or elevated BNP or Troponin are able to independently predict the outcome of patients with known cardiac disease and COVID-19 pneumonia. Methods and results: From March 7th to April 28th, forty consecutive patients with known cardiac disease (chronic coronary artery disease, n=38; atrial fibrillation, n = 7; valvular disease, n = 13) referred to our emergency department for symptoms of suspected COVID-19, laboratory diagnosis of COVID-19 and typical signs of viral pneumonia at chest CT were enrolled in the study. The only predictor of the composite end-point (all cause of death + invasive ventilation + thromboembolic event) was the lung involvement % at chest CT (OR: 1.06; 95%CI: 1.01–1.11, P = 0.02). In the multivariate analysis, the lung involvement % at chest CT was the only independent predictor of the composite end-point (OR: 1.06; 95%CI: 1.01–1.11, P = 0.034). Conclusions: The extent of lung involvement by COVID-19 is the only independent predictor of adverse outcome of patients and is predominant over the severity of cardiac disease.
AB - Background: Aim of the present study was to assess if the presence of high cardiovascular risk, left ventricle systolic dysfunction or elevated BNP or Troponin are able to independently predict the outcome of patients with known cardiac disease and COVID-19 pneumonia. Methods and results: From March 7th to April 28th, forty consecutive patients with known cardiac disease (chronic coronary artery disease, n=38; atrial fibrillation, n = 7; valvular disease, n = 13) referred to our emergency department for symptoms of suspected COVID-19, laboratory diagnosis of COVID-19 and typical signs of viral pneumonia at chest CT were enrolled in the study. The only predictor of the composite end-point (all cause of death + invasive ventilation + thromboembolic event) was the lung involvement % at chest CT (OR: 1.06; 95%CI: 1.01–1.11, P = 0.02). In the multivariate analysis, the lung involvement % at chest CT was the only independent predictor of the composite end-point (OR: 1.06; 95%CI: 1.01–1.11, P = 0.034). Conclusions: The extent of lung involvement by COVID-19 is the only independent predictor of adverse outcome of patients and is predominant over the severity of cardiac disease.
KW - cardiovascular disease
KW - Covid-19
KW - lung disease
KW - non-contrast CT scan
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U2 - 10.1016/j.ijcard.2020.10.006
DO - 10.1016/j.ijcard.2020.10.006
M3 - Article
C2 - 33038410
AN - SCOPUS:85092523131
VL - 323
SP - 292
EP - 294
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -