Entità dell'inibizione dell'aggregazione piastrinica ed eventi clinici: Nuove evidenze ottenute con prasugrel

Translated title of the contribution: Extent of platelet aggregation inhibition and clinical events: New evidence with prasugrel

Rosanna Abbate, Filippo Crea, Stefano De Servi, Erica Filippi, Gian Franco Gensini, Paolo Golino, Stefano Savonitto

Research output: Contribution to journalArticlepeer-review

Abstract

Clopidogrel in combination with aspirin is the recommended standard of care for reducing the occurrence of cardiovascular events in patients presenting with acute coronary syndromes; these protective effects of clopidogrel have been shown both in patients undergoing percutaneous coronary intervention (PCI) and in those treated with medical therapy alone. However, significant shortcomings still exist, including a delayed onset of action in platelet inhibition, individual response variability (with some patients being frankly hyporesponsive), and a prolonged time to recovery of platelet function following cessation of treatment. Among these, clopidogrel hyporesponsiveness seems to be particularly important, as a growing body of evidence suggests that residual platelet reactivity on clopidogrel is associated with a significant increase in the risk of developing adverse clinical events. Prasugrel is a novel, third-generation oral thienopyridine that is a specific, irreversible antagonist of the platelet adenosine 5′-diphosphate P2Y12 receptor. Prasugrel has more potent antiplatelet activity, faster onset of action, and less interpatient variability as compared to clopidogrel. These pharmacodynamic properties led prasugrel to be more effective in preventing ischemic events in patients with acute coronary syndromes undergoing PCI in the setting of the recent TRITON-TIMI 38 study. However, the greater protective effects toward ischemic events were partially counterbalanced by an increased risk of bleeding, particularly in patients with history of transient ischemic attack/stroke, in those with body weight

Translated title of the contributionExtent of platelet aggregation inhibition and clinical events: New evidence with prasugrel
Original languageItalian
Pages (from-to)127-137
Number of pages11
JournalGiornale Italiano di Cardiologia
Volume11
Issue number2
Publication statusPublished - Feb 2010

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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